Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

M. Keaton, Jacob; Kamali, Zoha; Xie, Tian; Vaez, Ahmad; Williams, Ariel; B. Goleva, Slavina; Ani, Alireza; Εvangelou, Εvangelos; N. Hellwege, Jacklyn; Yengo, Loic; J. Young, William; Traylor, Matthew; Giri, Ayush; Zheng, Zhili; Zeng, Jian; I. Chasman, Daniel; P. Morris, Andrew; J. Caulfield, Mark; Hwang, Shih-Jen; S. Kooner, Jaspal; Conen, David; Attia, John; C. Morrison, Alanna; J. F. Loos, Ruth; Kristiansson, Kati; Schmidt, Reinhold; A. Hicks, Andrew; P. Pramstaller, Peter; P. Nelson, Christopher; J. Samani, Nilesh; Risch, Lorenz; Gyllensten, Ulf; Melander, Olle; Riese, Harriëtte; F. Wilson, James; Campbell, Harry; S. Rich, Stephen; M. Psaty, Bruce; Lu, Yingchang; I. Rotter, Jerome; Guo, Xiuqing; Rice, Kenneth; Vollenweider, Péter; Sundström, Johan; Langenberg, Claudia; D. Tobin, Martin; Giedraitis, Vilmantas; Luan, Jian’an; Tuomilehto, Jaakko; Kutalik, Zoltán; Ripatti, Samuli; Salomaa, Veikko; Girotto, Giorgia; Trompet, Stella; Wouter Jukema, J.; van der Harst, Pim; M. Ridker, Paul; Giulianini, Franco; Vitart, Véronique; Goel, Anuj; Watkins, Hugh; E. Harris, Sarah; J. Deary, Ian; J. van der Most, Peter; J. Oldehinkel, Albertine; Keavney, Bernard; Hayward, Caroline; Campbell, Archie; Boehnke, Michael; J. Scott, Laura; Boutin, Thibaud; Mamasoula, Chrysovalanto; Järvelin, Marjo‐Riitta; Peters, Annette; Gieger, Christian; G. Lakatta, Edward; Cucca, Francesco; Hui, Jennie; Knekt, Paul; Enroth, Stefan; H. de Borst, Martin; Polašek, Ozren; Pina Concas, Maria; Catamo, Eulalia; Cocca, Massimiliano; Li-Gao, Ruifang; Hofer, Edith; Schmidt, Helena; Spedicati, Beatrice; Waldenberger, Melanie; P. Strachan, David; Laan, Maris; Teumer, Alexander; Dörr, Marcus; Guðnason, Vilmundur; P. Cook, James; Ruggiero, Daniela; Kolčić, Ivana; Boerwinkle, Eric; Traglia, Michela; Lehtimäki, Terho; Raitakari, Olli; D. Johnson, Andrew; Newton‐Cheh, Christopher; J. Brown, Morris; F. Dominiczak, Anna; J. Sever, Peter; Poulter, Neil; C. Chambers, John; Elosúa, Roberto; Siscovick, David; Esko, Tõnu; Metspalu, Andres; J. Strawbridge, Rona; Laakso, Markku; Hamsten, Anders; Hottenga, Jouke‐Jan; J. C. de Geus, Eco; D. Morris, Andrew; N. A. Palmer, Colin; M. Nolte, Ilja; Milaneschi, Yuri; Marten, Jonathan; F. Wright, Alan; Zeggini, Eleftheria; M. M. Howson, Joanna; J. O’Donnell, Christopher; D. Spector, Tim; A. Nalls, Mike; M. Simonsick, Eleanor; Liu, Ching‐Ti; M. van Duijn, Cornelia; S. Butterworth, Adam; N. Danesh, John; Menni, Cristina; J. Wareham, Nicholas; Khaw, Kay-Tee; V. Sun, Yan; W.F. Wilson, Peter; Cho, Kelly; M. Visscher, Peter; C. Denny, Joshua; Veteran Program, Million; Cohort Study, Lifelines; M. van Duijn, Cornelia; S. Butterworth, Adam; Vaez, Ahmad; Teumer, Alexander; D. Johnson, Andrew; D. Morris, Andrew; Peters, Annette; Goel, Anuj; Campbell, Archie; Keavney, Bernard; Hayward, Caroline; Newton‐Cheh, Christopher; P. Nelson, Christopher; I. Chasman, Daniel; Levy, Daniel; Ruggiero, Daniela; J. C. de Geus, Eco; Hofer, Edith; Zeggini, Eleftheria; Boerwinkle, Eric; Girotto, Giorgia; R. Warren, Helen; Watkins, Hugh; Kolčić, Ivana; Wouter Jukema, J.; Hui, Jennie; M. M. Howson, Joanna; Sundström, Johan; C. Chambers, John; N. Danesh, John; Risch, Lorenz; J. Caulfield, Mark; Laakso, Markku; D. Tobin, Martin; H. De Borst, Martin; Waldenberger, Melanie; J. Samani, Nilesh; Melander, Olle; Raitakari, Olli; Polašek, Ozren; B. Munroe, Patricia; M. Ridker, Paul; van der Harst, Pim; Elosúa, Roberto; Ripatti, Samuli; Lehtimäki, Terho; J. Young, William; Kamali, Zoha; Kutalik, Zoltán; Levy, Daniel; L. Edwards, Todd; B. Munroe, Patricia; Snieder, Harold; R. Warren, Helen

doi:10.1038/s41588-024-01714-w

Public

Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits

Published in Nature Genetics • Apr 30, 2024

Authors:

Jacob M. Keaton

Zoha Kamali

Tian Xie

Abstract

Abstract Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals ( P < 5 × 10 −8 ) from the largest single-stage blood pressure (BP) genome-wide association study to date ( n = 1,028,980 European individuals...

Subject

Biology

Polygenic risk score

Multifactorial Inheritance

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