The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development

Nakagawa, Shoma; Carnevali, Davide; Tan, Xiangtian; J. Alvarez, Mariano; Parfitt, David-Emlyn; Di Vicino, Umberto; Arumugam, K.; Shin, William; Aranda, Sergi; Normanno, Davide; Sebastián-Pérez, Rubén; Cannatá, Chiara; Cortes, Paola; Victoria Neguembor, Maria; M. Shen, Michael; Califano, Andrea; Pia Cosma, Maria

doi:10.1016/j.stemcr.2024.04.004

Public

The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development

Published in Stem Cell Reports • May 1, 2024

Authors:

Shoma Nakagawa

Davide Carnevali

Xiangtian Tan

Abstract

Embryo size, specification, and homeostasis are regulated by a complex gene regulatory and signaling network. Here we used gene expression signatures of Wnt-activated mouse embryonic stem cell (mESC) clones to reverse engineer an mESC regulatory network. We identify NKX1-2 as a novel master regulato...

Subject

Biology

Cell biology

Wnt signaling pathway

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