The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development.

S, Nakagawa; D, Carnevali; X, Tan; MJ, Alvarez; DE, Parfitt; Vicino U, Di; K, Arumugam; W, Shin; S, Aranda; D, Normanno; R, Sebastian-Perez; C, Cannatá; P, Cortes; MV, Neguembor; MM, Shen; A, Califano; MP, Cosma

doi:10.1016/j.stemcr.2024.04.004

Public

The Wnt-dependent master regulator NKX1-2 controls mouse pre-implantation development.

Shared by NobleBlocks on May 2, 2024 • 12:00 AM UTC

Authors:

Nakagawa S

Carnevali D

Tan X

Abstract

Embryo size, specification, and homeostasis are regulated by a complex gene regulatory and signaling network. Here we used gene expression signatures of Wnt-activated mouse embryonic stem cell (mESC) clones to reverse engineer an mESC regulatory network. We identify NKX1-2 as a novel master regulato...

Subject

Nucleolus

Embryonic stem cell

Mouse embryo

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