Accurate structure prediction of biomolecular interactions with AlphaFold 3

Abramson, Josh; Adler, Jonas; Dunger, Jack; Evans, Richard; Green, Tim; Pritzel, Alexander; Ronneberger, Olaf; Willmore, Lindsay; J. Ballard, Andrew; Bambrick, Joshua; W. Bodenstein, Sebastian; A. Evans, David; Hung, Chia-Chun; O’Neill, Michael; Reiman, David; Tunyasuvunakool, Kathryn; Wu, Zachary; Žemgulytė, Akvilė; Arvaniti, Eirini; Beattie, Charles; Bertolli, Ottavia; Bridgland, Alex; V. Cherepanov, Alexey; Congreve, Miles; I. Cowen-Rivers, Alexander; Cowie, Andrew; Figurnov, Michael; B. Fuchs, Fabian; Gladman, Hannah; Jain, Rishub; A. Khan, Yousuf; M. R. Low, Caroline; Perlin, Kuba; Potapenko, Anna; Savy, Pascal; Singh, Sukhdeep; Stecuła, Adrian; Thillaisundaram, Ashok; Tong, Catherine; Yakneen, Sergei; D. Zhong, Ellen; Zieliński, Michał; Žídek, Augustin; Bapst, Victor; Kohli, Pushmeet; Jaderberg, Max; Hassabis, Demis; Jumper, John

doi:10.1038/s41586-024-07487-w

Public

Accurate structure prediction of biomolecular interactions with AlphaFold 3

Published in Nature • May 8, 2024

Authors:

Josh Abramson

Jonas Adler

Jack Dunger

Abstract

Abstract The introduction of AlphaFold 2 1 has spurred a revolution in modelling the structure of proteins and their interactions, enabling a huge range of applications in protein modelling and design 2–6 . Here we describe our AlphaFold 3 model with a substantially updated diffusion-based architect...

Subject

Computational biology

Computer science

Biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!