Neurofilament Light Chain as a Biomarker of Global Cognition in Individuals With Possible Vascular Mild Cognitive Impairment

Gaur, Amish; Gallagher, Damien; Herrmann, Nathan; Jenny Chen, Jinghan; Marzolini, Susan; Oh, Paul; Amemiya, Yutaka; Seth, Arun; Kiss, Alex; L. Lanctôt, Krista

doi:10.1177/08919887241254469

Public

Neurofilament Light Chain as a Biomarker of Global Cognition in Individuals With Possible Vascular Mild Cognitive Impairment

Shared by NobleBlocks on May 17, 2024 • 12:00 AM UTC

Authors:

Amish Gaur

Damien Gallagher

Nathan Herrmann

Abstract

Background Neurofilament Light Chain (NfL) is a biomarker of axonal injury elevated in mild cognitive impairment (MCI) and Alzheimer’s disease dementia. Blood NfL also inversely correlates with cognitive performance in those conditions. However, few studies have assessed NfL as a biomarker of global...

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