Urokinase-Type Plasminogen Activator Receptor (uPAR) in Inflammation and Disease: A Unique Inflammatory Pathway Activator

Hamada, Mostafa; Varkoly, Kyle; Riyadh, Omer; Beladi, Roxana; Munuswamy‐Ramanujam, Ganesh; Rawls, Alan; Wilson‐Rawls, Jeanne; Chen, Hao; McFadden, Grant; Lucas, Alexandra

doi:10.3390/biomedicines12061167

Public

Urokinase-Type Plasminogen Activator Receptor (uPAR) in Inflammation and Disease: A Unique Inflammatory Pathway Activator

Published in Biomedicines • May 24, 2024

Authors:

Mostafa Hamada

Kyle Varkoly

Omer Riyadh

Abstract

The urokinase-type plasminogen activator receptor (uPAR) is a unique protease binding receptor, now recognized as a key regulator of inflammation. Initially, uPA/uPAR was considered thrombolytic (clot-dissolving); however, recent studies have demonstrated its predominant immunomodulatory functions i...

Subject

Urokinase receptor

SuPAR

Vitronectin

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