Ancient Plasmodium genomes shed light on the history of human malaria

Michel, Megan; Skourtanioti, Eirini; Pierini, Federica; K. Guevara, Evelyn; Mötsch, Angela; Kocher, Arthur; Barquera, Rodrigo; A. Bianco, Raffaela; Carlhoff, Selina; Bove, Lorenza; Freilich, Suzanne; Giffin, Karen; R. Hermes, Taylor; Hiß, Alina; Knolle, Florian; A. Nelson, Elizabeth; U. Neumann, Gunnar; Papac, Luka; Penske, Sandra; B. Rohrlach, Adam; Salem, Nada; Semerau, Lena; Villalba‐Mouco, Vanessa; Abadie, Isabelle; Aldenderfer, Mark; Beckett, Jessica; Brown, Matthew; Campus, Franco; Chenghwa, Tsang; Cruz Berrocal, María; Damašek, Ladislav; Sara Duffett Carlson, Kellie; Durand, Raphaël; Ernée, Michal; Fântăneanu, Cristinel; Frenzel, H.; García Atiénzar, Gabriel; Guillén, Sonia; Hsieh, Ellen; Karwowski, Maciej; J. Kelvin, David; Kelvin, Nikki; Khokhlov, Alexander; Kinaston, Rebecca; Korolev, Arkadii; Krettek, Kim-Louise; Küßner, Mario; Lai, Luca; Look, Cory; Majander, Kerttu; Mandl, Kirsten; Mazzarello, Vittorio; McCormick, Michael; Paz de Miguel Ibáñez, María; Murphy, Reg; E. Németh, Rita; Nordqvist, Kerkko; Novotny, Friederike; Obenaus, Martin; Olmo-Enciso, Lauro; Onkamo, Päivi; Orschiedt, Jörg; Patrushev, Valerii; Peltola, Sanni; Romero, Alejandro; Rubino, Salvatore; Sajantila, Antti; C. Salazar‐García, Domingo; Serrano, Elena; Shaydullaev, Shapulat; Sias, Emanuela; Šlaus, Mario; Stančo, Ladislav; Swanston, Treena; Teschler‐Nicola, Maria; Valentin, Frédérique; Van de Vijver, Katrien; L. Varney, Tamara; Vigil-Escalera Guirado, Alfonso; K. Waters, Christopher; Weiss‐Krejci, Estella; Winter, Eduard; C. Lamnidis, Thiseas; Prüfer, Kay; Nägele, Kathrin; A. Spyrou, Maria; Schiffels, Stephan; W. Stockhammer, Philipp; Haak, Wolfgang; Posth, Cosimo; Warinner, Christina; I. Bos, Kirsten; Herbig, Alexander; Krause, Johannes

doi:10.1038/s41586-024-07546-2

Public

Ancient Plasmodium genomes shed light on the history of human malaria

Published in Nature • Jun 12, 2024

Authors:

Megan Michel

Eirini Skourtanioti

Federica Pierini

Abstract

Abstract Malaria-causing protozoa of the genus Plasmodium have exerted one of the strongest selective pressures on the human genome, and resistance alleles provide biomolecular footprints that outline the historical reach of these species 1 . Nevertheless, debate persists over when and how malaria p...

Subject

Malaria

Plasmodium (life cycle)

Genome

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