An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

Vacca, Michèle; Kamzolas, Ioannis; Mørch Harder, Lea; Oakley, Fiona; Trautwein, Christian; Hatting, Maximilian; T. Ross, Trenton; Bernardo, Barbara; Oldenburger, Anouk; Toftegaard Hjuler, Sara; Ksiazek, Iwona; Lindén, Daniel; Schuppan, Detlef; Rodríguez‐Cuenca, Sergio; Manuela Tonini, Maria; R. Castañeda, Tamara; Kannt, Aimo; M. P. Rodrigues, Cecília; Cockell, Simon; Govaere, Olivier; K. Daly, Ann; Allison, Michael; Honnens de Lichtenberg, Kristian; Ook Kim, Yong; Lindblom, Anna; Oldham, Stephanie; Andréasson, Anne‐Christine; Schlerman, Franklin; Marioneaux, Jonathon; J. Sanyal, Arun; B. Afonso, Marta; Younes, Ramy; Amano, Yuichiro; L. Friedman, Scott; Wang, Shuang; Bhattacharya, Dipankar; J. Simon, Eric; Paradis, Valérie; D. Burt, Alastair; Maria Grypari, Ioanna; Davies, Susan; Driessen, Ann; Yashiro, Hiroaki; Elisabeth Pors, Susanne; Andersen, M; Feigh, Michael; Yunis, Carla; Bédossa, Pierre; Stewart, Michelle; Cater, Heather; Wells, Sara; M. Schattenberg, Jörn; M. Anstee, Quentin; LITMUS Investigators, The; M. Anstee, Quentin; K. Daly, Ann; Cockell, Simon; Tiniakos, Dina; Bédossa, Pierre; D. Burt, Alastair; Oakley, Fiona; J. Cordell, Heather; P. Day, Christopher; Wonders, Kristy; Missier, Paolo; McTeer, Matthew; Vale, Luke; Oluboyede, Yemi; Breckons, Matt; Boyle, Jo; M. Bossuyt, Patrick; Zafarmand, Hadi; Vali, Yasaman; Lee, Jenny; Nieuwdorp, Max; G. Holleboom, Adriaan; Angelakis, Athanasios; Verheij, Joanne; Ratziu, Vlad; Clément, Karine; Patiño‐Navarrete, Rafael; Pais, Raluca; Paradis, Valérie; Schuppan, Detlef; M. Schattenberg, Jörn; Surabattula, Rambabu; Rani Myneni, Sudha; Ook Kim, Yong; K. Straub, Beate; Vidal-Puig, Antonio; Vacca, Michèle; Rodrigues-Cuenca, Sergio; Allison, Mike; Kamzolas, Ioannis; Petsalaki, Evangelia; Campbell, Mark; Lelliott, Chris; Davies, Susan; Orešič, Matej; Hyötyläinen, Tuulia; McGlinchey, Aidan; M. Mato, José; Millet, Óscar; Dufour, Jean‐François; Berzigotti, Annalisa; Masoodi, Mojgan; F. Lange, Naomi; Pavlides, Michael; Harrison, Stephen; Neubauer, Stefan; Cobbold, Jeremy; E. Mózes, Ferenc; Akhtar, Salma; Olodo-Atitebi, Seliat; Banerjee, Rajarshi; Shumbayawonda, Elizabeth; Dennis, Andrea; Andersson, Anneli; Wigley, Ioan; Romero‐Gómez, Manuel; Gómez-González, Emilio; Ampuero, Javier; Castell, Javier; Gallego‐Durán, Rocío; Fernández-Lizaranzu, Isabel; Montero‐Vallejo, Rocío; Karsdal, M.A.; Guldager Kring Rasmussen, Daniel; Julie Leeming, Diana; Sinisi, Antonia; Musa, Kishwar; Sandt, Estelle; Manuela Tonini, Maria; Bugianesi, Elisabetta; Rosso, Chiara; Armandi, Angelo; Marra, Fabio; Gastaldelli, Amalia; Svegliati, Gianluca; Boursier, Jérôme; Francque, Sven; Vonghia, Luisa; Verrijken, An; Dirinck, Eveline; Driessen, Ann; Ekstedt, Mattias; Kechagias, Stergios; Yki‐Järvinen, Hannele; Porthan, Kimmo; Arola, Johanna; W. C. van Mil, Saskia; Papatheodoridis, George; Cortez‐Pinto, Helena; Paula Silva, Ana; M. P. Rodrigues, Cecília; Valenti, Luca; Pelusi, Serena; Petta, Salvatore; Pennisi, Grazia; Miele, Luca; Liguori, Antonio; Geier, Andreas; Rau, Monika; Trautwein, Christian; Reißing, Johanna; P. Aithal, Guruprasad; Francis, Susan; Palaniyappan, Naaventhan; R. Bradley, Christopher; Hockings, Paul; Schneider, Moritz; N. Newsome, Philip; G. Hübscher, Stefan; Wenn, David; Magnanensi, Jérémy; Trylesinski, Aldo; Mayo, Rebeca; Alonso, Cristina; L. Duffin, Kevin; W. Perfield, James; Chen, Yu; L. Hartman, Mark; Yunis, Carla; Miller, Melissa; Chen, Yan; McLeod, Euan; T. Ross, Trenton; Bernardo, Barbara; Schölch, Corinna; Ertle, Judith; Younes, Ramy; O. Coxson, Harvey; Simon, Eric; Gogain, Joseph; Ostroff, Rachel; Alexander, Leigh; Biegel, Hannah; Skalshøi Kjær, Mette; Mørch Harder, Lea; Al‐Sari, Naba; Skovgård Veidal, Sanne; Oldenburger, Anouk; Ellegaard, Jens; Balp, M.M.; L. Jennings, Lori; Martić, Miljen; Löffler, Jürgen; Applegate, Douglas; Torstenson, Richard; Lindén, Daniel; Fournier‐Poizat, Céline; Llorca, Anne; Kalutkiewicz, Michael; Pepin, Kay; Ehman, Richard; Horan, Gerald; Ho, Gideon; Tai, Dean; Chng, Elaine; Xiao, Teng; D. Patterson, Scott; N. Billin, Andrew; Doward, Lynda; Twiss, James; Thakker, Paresh; Derdák, Zoltán; Yashiro, Hiroaki; Landgren, Henrik; Lackner, Carolin; S.H. Gouw, Annette; Hytiroglou, Prodromos; Govaere, Olivier; A. Brass, Clifford; Tiniakos, Dina; W. Perfield, James; Petsalaki, Evangelia; K. Davidsen, Peter; Vidal-Puig, Antonio

doi:10.1038/s42255-024-01043-6

Public

An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

Published in Nature Metabolism • Jun 12, 2024

Authors:

Michèle Vacca

Ioannis Kamzolas

Lea Mørch Harder

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as non-alcoholic fatty liver disease, encompasses steatosis and metabolic dysfunction-associated steatohepatitis (MASH), leading to cirrhosis and hepatocellular carcinoma. Preclinical MASLD research is mainly performe...

Subject

Steatohepatitis

Fatty liver

Steatosis

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