RNA-encoded Interleukin 2 with Extended Bioavailability Amplifies RNA Vaccine–Induced Antitumor T-cell Immunity

Peters, Daniel; M. Kranz, Lena; Eisel, David; Diken, Mustafa; Kreiter, Sebastian; Türeci, Özlem; Sahin, Ugur; Vormehr, Mathias

doi:10.1158/2326-6066.cir-23-0701

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RNA-encoded Interleukin 2 with Extended Bioavailability Amplifies RNA Vaccine–Induced Antitumor T-cell Immunity

Shared by NobleBlocks on Jun 17, 2024 • 12:00 AM UTC

Authors:

Daniel Peters

Lena M. Kranz

David Eisel

Abstract

Abstract Interleukin 2 (IL-2) is a crucial cytokine in T-cell immunity, with a promising potential in cancer vaccines. However, therapeutic application of IL-2 is hampered by its short half-life and substantial toxicity. This study reports preclinical characterization of a mouse serum albumin–IL-2 f...

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