Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice

Gomez-Murcia, Victoria; Launay, Agathe; Carvalho, Kévin; Burgard, Anaëlle; Meriaux, Céline; Caillierez, Raphaëlle; Eddarkaoui, Sabiha; Kilinc, Devrim; Siedlecki-Wullich, Dolores; Besegher, Mélanie; Bégard, Séverine; Thiroux, Bryan; Jung, Matthieu; Nebie, Ouada; Wisztorski, Maxence; Déglon, Nicole; Montmasson, Claire; Bemelmans, Alexis-Pierre; Hamdane, Malika; Lebouvier, Thibaud; Vieau, Didier; Fournier, Isabelle; Buee, Luc; Lévi, Sabine; V Lopes, Luisa; Boutillier, Anne-Laurence; Faivre, Emilie; Blum, David

doi:10.1093/brain/awae113

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Neuronal A2A receptor exacerbates synapse loss and memory deficits in APP/PS1 mice

Shared by NobleBlocks on Jul 5, 2024 • 12:00 AM UTC

Authors:

Victoria Gomez-Murcia

Agathe Launay

Kévin Carvalho

Abstract

Abstract Early pathological upregulation of adenosine A2A receptors (A2ARs), one of the caffeine targets, by neurons is thought to be involved in the development of synaptic and memory deficits in Alzheimer’s disease (AD) but mechanisms remain ill-defined. To tackle this question, we promoted a neur...

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