Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Ekanem, Emmanuel; Neužil, Petr; Reichlin, Tobias; Kautzner, J; van der Voort, Pepijn; Jaı̈s, Pierre; Chierchia, Gian‐Battista; Bulava, Alan; Blaauw, Yuri; Skála, Tomáš; Fiala, Martin; Duytschaever, Mattias; Széplaki, Gábor; Schmidt, Boris; Massoullié, Grégoire; Neven, Kars; Thomas, Olivier; Vijgen, Johan; Gandjbakhch, Estelle; Scherr, Daniel; Johannessen, Arne; Keane, David; Bovéda, Serge; Maury, Philippe; García-Bolao, Ignacio; Anić, Ante; S. Hansen, Peter; Raczka, Franck; Lepillier, Antoine; Guyomar, Yves; Gupta, Dhiraj; M. van Opstal, Jurren; Defaye, Pascal; Sticherling, Christian; Sommer, Philipp; Kučera, Pavel; Osca, Joaquín; Tabrizi, Fariborz; Roux, Antoine; W. Gramlich, Michael; Bianchi, Stefano; Adragão, Pedro; Solimene, Francesco; Tondo, Claudio; Dello Russo, Antonio; Schreieck, Jürgen; Luik, Armin; R. Rana, Obaida; Frommeyer, Gerrit; Anselme, Frédéric; Kreis, Ingo; Rosso, Raphaël; Metzner, Andreas; Gellér, László; H. Baldinger, Samuel; Ferrero, Ángel; Willems, Stephan; Goette, Andreas; Mellor, Greg; Mathew, Shibu; Szumowski, Łukasz; Richard Tilz, Roland; Iacopino, Saverio; Karl Jacobsen, Peter; George, Andrikopoulos; Osmančík, Pavel; G. Spitzer, Stefan; Balasubramaniam, Richard; Shokor Parwani, Abdul; Deneke, Thomas; Główniak, Andrzej; Rossillo, Antonio; Pürerfellner, Helmut; Duncker, David; Reil, P; Arentz, Thomas; Steven, Daniel; J. Olalla, Juan; S.S.G. de Jong, Jonas; Wakili, Reza; Abbey, Sélim; Timo, Gottschling; Asso, Antonio; Wong, Tom; Pierre, Bertrand; Christian Ewertsen, Niels; Bergau, Leonard; Lozano-Granero, Cristina; Rivero, Maximo; Breitenstein, Alexander; Inkovaara, J; Fareh, Samir; Gabriel Lațcu, Decebal; Linz, Dominik; Müller, Patrick; Ramos‐Maqueda, Javier; Beiert, Thomas; Themistoclakis, Sakis; Große Meininghaus, Dirk; Stix, G; Tzeis, Stylianos; Baran, Jakub; Almroth, Henrik; Muñoz, Daniel; de Sousa, João; Efremidis, Michalis; Balsam, Paweł; Petrů, Jan; Küffer, Thomas; Peichl, Petr; Dekker, Lukas; G. Della Rocca, Domenico; Moravec, Ondřej; Funasako, Moritoshi; Knecht, Sébastien; Jauvert, Gael; Chun, Julian; Eschalier, Romain; Füting, Anna; Zhao, Alexandre; Koopman, Pieter; Laredo, Mikaël; Manninger, Martin; Hansen, Jim; O’Hare, Daniel; Rollin, Anne; Jurišić, Zrinka; Fink, Thomas; Chaumont, Corentin; Rillig, Andreas; Gunawerdene, Melanie; Martin, Claire; Kirstein, Bettina; Nentwich, Karin; Lehrmann, Heiko; Sultan, Arian; Bohnen, Jan; K. Turagam, Mohit; Y. Reddy, Vivek

doi:10.1038/s41591-024-03114-3

Public

Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study

Published in Nature Medicine • Jul 1, 2024

Authors:

Emmanuel Ekanem

Petr Neužil

Tobias Reichlin

Abstract

Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical data are suggestive of some degree of preferentiality to myocardial tissue ablation without damage to adjacent structures. Here in the MANIFEST-17K stu...

Subject

Atrial fibrillation

Medicine

Cardiology

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