Spiky Gold Nanoparticles, a Nanoscale Approach to Enhanced Ex Vivo T-Cell Activation

Esmaeili, Fatemeh; Leo Wu, Yuhao; Wang, Zongjie; Abdrabou, Abdalla; B. Juska, Vuslat; Zargartalebi, Hossein; D. Flynn, Connor; W. Odom, Teri; H. Sargent, Edward; O. Kelley, Shana

doi:10.1021/acsnano.4c07306

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Spiky Gold Nanoparticles, a Nanoscale Approach to Enhanced Ex Vivo T-Cell Activation

Published in ACS Nano • Jul 30, 2024

Authors:

Fatemeh Esmaeili

Yuhao Leo Wu

Zongjie Wang

Abstract

While existing synthetic technologies for ex vivo T-cell activation face challenges like suboptimal expansion rates and low effectiveness, artificial antigen-presenting cells (aAPCs) hold great promise for enhanced T-cell based therapies. In particular, gold nanoparticles (AuNPs), known for their bi...

Subject

Colloidal gold

Nanotechnology

Biocompatibility

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