Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

Skerget, Sheri; Peñaherrera, Daniel; Chari, Ajai; Jagannath, Sundar; S. Siegel, David; Vij, Ravi; Orloff, Gregory; Jakubowiak, Andrzej; Niesvizky, Rubén; Liles, Darla; G. Berdeja, Jesús; Levy, Moshe; L. Wolf, Jeffrey; Z. Usmani, Saad; MMRF CoMMpass Network, The; M. Rifkin, Robert; R. Meehan, Kenneth; Benson, Don; A. Zonder, Jeffrey; L. Ascensão, João; Gasparetto, Cristina; Hernández, Miguel‐Teodoro; Trudel, Suzanne; R. Dakhil, Shaker; J. Bahlis, Nizar; Vazquez Paganini, Juan; Rios, Pablo; Sampol, Antònia; Mannem, Siva; Silbermann, Rebecca; A. Lunning, Matthew; P. Chu, Michael; Milner, Carter; Harroff, Allyson; E. Graham, Mark; H. Shao, Spencer; Dodlapati, Jyothi; Fernández de Larrea, Carlos; Klein, Leonard; Kuzma, Charles; Fonseca, Rafaël; Azaceta, Gemma; Granell, Miquel; Martínez‐Chamorro, Carmen; Balaraman, Rama; Fernandes da Silva, Carlos; Chinea, Anabelle; Costello, Caitlin; Kambhampati, Suman; Andrew Lewis, DeQuincy; L. Grossbard, Michael; J. Yost, Kathleen; Robles, Robert; Sébag, Michaël; Harris, Wayne; R. Ngaiza, Justinian; Bär, Michael; Shieh, Marie; Min, Fredrick; A. Onitilo, Adedayo; Volterra, Fabio; Wachsman, William; Yalamachili, Madhuri; Abella, Eugènia; J. Anderson, Larry; Bargay, Joan; Hassoun, Hani; C Hsu, Gerald; Kaya, Hakan; R. Menter, Alex; Patel, Dilip; Richards, Donald; B. Solomon, William; F. Anderson, Robert; Chandra, Sumeet; Á. Conde, Miguel; Girnius, Saulias; Matkiwsky, May; Krsnik, Isabel; Kumar, Shaji; Oriol, Albert; Rodríguez, Paula; Roy, Vivek; Srinivas, Shanti; G. Steis, Ronald; Christofferson, Austin; Nasser, Sara; L. Aldrich, Jessica; Legendre, Christophe; A. Benard, Brooks; S. Miller, C.; Turner, Bryce; Kurdoglu, Ahmet; Washington, Megan; D. Yellapantula, Venkata; Adkins, Jonathan; Cuyugan, Lori; Boateng, Martin; Helland, Adrienne; Kyman, Shari; McDonald, Jackie; Reiman, Rebecca; Stephenson, Kristi; E. Tassone, Erica; Blanski, Alex; Livermore, Brianne; Kirchhoff, Meghan; C. Rohrer, Daniel; D’Agostino, Mattia; Gambella, Manuela; Collison, Kimberly; Stumph, Jennifer; Kidd, Pam; Donnelly, Andrea; Zaugg, Barbara; Toone, Maureen; McBride, Kyle; DeRome, Mary; Rogers, Jennifer; W. Craig, David; S. Liang, Winnie; C. Gutiérrez, Norma; D. Jewell, Scott; D. Carpten, John; C. Anderson, Kenneth; Jay Cho, Hearn; Auclair, Daniel; Lonial, Sagar; J. Keats, Jonathan

doi:10.1038/s41588-024-01853-0

Public

Comprehensive molecular profiling of multiple myeloma identifies refined copy number and expression subtypes

Published in Nature Genetics • Aug 19, 2024

Authors:

Sheri Skerget

Daniel Peñaherrera

Ajai Chari

Abstract

Multiple myeloma is a treatable, but currently incurable, hematological malignancy of plasma cells characterized by diverse and complex tumor genetics for which precision medicine approaches to treatment are lacking. The Multiple Myeloma Research Foundation’s Relating Clinical Outcomes in Multiple M...

Subject

Biology

Multiple myeloma

Gene expression profiling

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