Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines.

Rían W, Manville,; Ryan F, Yoshimura,; Andriy V, Yeromin,; Derk, Hogenkamp,; der Horst, Jennifer, van; Angel, Zavala,; Sonia, Chinedu,; Grey, Arena,; Emma, Lasky,; Mark, Fisher,; Christopher R, Tracy,; Shivashankar, Othy,; Thomas A, Jepps,; Michael D, Cahalan,; Geoffrey W, Abbott,

doi:10.1038/s42003-024-06752-y

Public

Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines.

Published in Communications biology • Aug 28, 2024

Authors:

Manville, Rían W

Yoshimura, Ryan F

Yeromin, Andriy V

Abstract

Pain and inflammation contribute immeasurably to reduced quality of life, yet modern analgesic and anti-inflammatory therapeutics can cause dependence and side effects. Here, we screened 1444 plant extracts, prepared primarily from native species in California and the United States Virgin Islands, a...

Subject

Anti-Inflammatory Agents

Analgesics

Animals

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