Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and Neurodegeneration.

Ana Filipa, Sobral,; Andrea, Cunha,; Vera, Silva,; Eva, Gil-Martins,; Renata, Silva,; Daniel José, Barbosa,

doi:10.3390/ijms25179339

Public

Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and Neurodegeneration.

Published in International journal of molecular sciences • Aug 28, 2024

Authors:

Sobral, Ana Filipa

Cunha, Andrea

Silva, Vera

Abstract

Cellular metabolism is crucial for various physiological processes, with folate-dependent one-carbon (1C) metabolism playing a pivotal role. Folate, a B vitamin, is a key cofactor in this pathway, supporting DNA synthesis, methylation processes, and antioxidant defenses. In dividing cells, folate fa...

Subject

cancer

folate

folate cycle

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