Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases

Saggau, Carina; Bächer, Petra; Esser, Daniela; Rasa, Mahdi; Meise, Silja; Mohr, Nicola; Kohlstedt, Nora; Hutloff, Andreas; Schacht, Sarah-Sophie; Dargvainiene, Justina; Rios Martini, Gabriela; Hanja Stürner, Klarissa; Schröder, Ina; Markewitz, Robert; Hartl, Johannes; Hastermann, Maria; Duchow, Ankelien; Schindler, Patrick; Becker, Mareike; Bautista, Carolin; Gottfreund, Judith; Walter, Jörn; K. Polansky, Julia; Yang, Mingxing; Naghavian, Reza; Wendorff, Mareike; Schuster, Ev-Marie; Dahl, Andreas; Petzold, A.; Reinhardt, Susanne; Franke, André; Wieczorek, Marek; Henschel, Lea; Berger, Daniel; Heine, Guido; M. Holtsche, Maike; Häußler, Vivien; Peters, Christian; Schmidt, Enno; Fillatreau, Simon; H. Busch, Dirk; Wandinger, Klaus‐Peter; Schober, Kilian; Martinꝉ, Roland; Paul, Friedemann; Leypoldt, Frank; Scheffold, Alexander

doi:10.1016/j.immuni.2024.08.005

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Autoantigen-specific CD4+ T cells acquire an exhausted phenotype and persist in human antigen-specific autoimmune diseases

Published in Immunity • Sep 2, 2024

Authors:

Carina Saggau

Petra Bächer

Daniela Esser

Abstract

Pro-inflammatory autoantigen-specific CD4 + T helper (auto-Th) cells are central orchestrators of autoimmune diseases (AIDs). We aimed to characterize these cells in human AIDs with defined autoantigens by combining human leukocyte antigen (HLA)-tetramer-based and activation-based multidimensional e...

Subject

Biology

Phenotype

Immunology

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