Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection

Yang, Liuliu; Han, Yuling; Zhang, Tuo; Dong, Xue; Ge, Jian; Roy, Aadita; Zhu, Jiajun; Lu, Tiankun; Jeya Vandana, J.; de Silva, Neranjan; C. Robertson, Catherine; Xiang, Jenny; Pan, Chendong; Sun, Yanjie; Que, Jianwen; Evans, Todd; Liu, Chengyang; Wang, Wei; Naji, Ali; C.J. Parker, Stephen; E. Schwartz, Robert; Chen, Shuibing

doi:10.1016/j.stem.2024.08.007

Public

Human vascularized macrophage-islet organoids to model immune-mediated pancreatic β cell pyroptosis upon viral infection

Published in Cell stem cell • Sep 2, 2024

Authors:

Liuliu Yang

Yuling Han

Tuo Zhang

Abstract

There is a paucity of human models to study immune-mediated host damage. Here, we utilized the GeoMx spatial multi-omics platform to analyze immune cell changes in COVID-19 pancreatic autopsy samples, revealing an accumulation of proinflammatory macrophages. Single-cell RNA sequencing (scRNA-seq) an...

Subject

Pyroptosis

Proinflammatory cytokine

Organoid

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