Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy

Wang, Junyan; Zhuang, Haowen; Jia, Lianqun; He, Xinyong; Zheng, Sicheng; Ji, Kangshou; Xie, Kang; Tong, Ying; Zhang, Ying; Li, Chun; Chang, Xing

doi:10.7150/ijbs.95853

Public

Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy

Published in International Journal of Biological Sciences • Jan 1, 2024

Authors:

Junyan Wang

Haowen Zhuang

Lianqun Jia

Abstract

This study investigated the mechanism by which NR4A1 regulates mitochondrial fission factor (Mff)-related mitochondrial fission and FUN14 domain 1 (FUNDC1)-mediated mitophagy following cardiac ischemia-reperfusion injury(I/R). Our findings showed that the damage regulation was positively correlated ...

Subject

Mitophagy

Mitochondrial fission

Subfamily

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