Phage-antibiotic synergy suppresses resistance emergence of
            <i>Klebsiella pneumoniae</i>
            by altering the evolutionary fitness

Qin, Kunhao; Shi, Xing; Yang, Kai; Xu, Qiuqing; Wang, Fuxing; Chen, Senxiong; Xu, Tingting; Liu, Jinquan; Wen, Wangrong; Chen, Rongchang; Liu, Zheng; Cui, Li; Zhou, Kai

doi:10.1128/mbio.01393-24

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Phage-antibiotic synergy suppresses resistance emergence of Klebsiella pneumoniae by altering the evolutionary fitness

Shared by NobleBlocks on Oct 16, 2024 • 12:00 AM UTC

Authors:

Kunhao Qin

Xing Shi

Kai Yang

Abstract

ABSTRACT Phage-antibiotic synergy (PAS) represents a superior treatment strategy for pathogen infections with less probability of resistance development. Here, we aim to understand the molecular mechanism by which PAS suppresses resistance in terms of population evolution. A novel hypervirulent Kleb...

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