Spns1 is an iron transporter essential for megalin-dependent endocytosis

Beenken, Andrew; Shen, Tian; Jin, Guangchun; Ghotra, Aryan; Xu, Katherine; Nesanir, Kivanc; E. Sturley, Rachel; Vijayakumar, Soundarapandian; Kahn, Atlas; Levitman, Abraham; Stauber, Jacob; Y. Chavez, Estefania; Y. Robbins-Juarez, Shelief; Hao, Luke; B. Field, Thomas; Erdjument‐Bromage, Hediye; A. Neubert, Thomas; Shapiro, Lawrence; Qiu, Andong; Barasch, Jonathan

doi:10.1152/ajprenal.00172.2024

Public

Spns1 is an iron transporter essential for megalin-dependent endocytosis

Published in American Journal of Physiology-Renal Physiology • Sep 12, 2024

Authors:

Andrew Beenken

Tian Shen

Guangchun Jin

Abstract

Spns1 mediates a novel iron conductance essential during embryogenesis. Spns1 knockout leads to endocytic and lysosomal defects, accompanied by iron overload in the kidney. Reversal of iron overload by restricting dietary iron or by concurrent knockout of the iron transporter, DMT1 rescued the endoc...

Subject

Endocytic cycle

Endocytosis

Pinocytosis

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