Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: a phase 3b/4 trial

Harbeck, Nadia; Ciruelos, Eva; Jérusalem, Guy; Müller, Volkmar; Niikura, Naoki; Viale, Giuseppe; Bartsch, Rupert; Kurzeder, Christian; J. Higgins, Michaela; M. Connolly, Roisín; Baron‐Hay, Sally; Gión, María; Guarneri, Valentina; Bianchini, Giampaolo; Wildiers, Hans; Escrivá-de-Romaní, Santiago; Prahladan, Manoj; Bridge, Helen; Kuptsova‐Clarkson, Nataliya; Scotto, Nana; Verma, Sunil; U. Lin, Nancy; DESTINY-Breast12 study group, the; Yeo, Belinda; McCarthy, Nicole; McCartney, Amelia; Clay, Timothy; Murray, Nicholas; Gombos, Andrea; Collignon, Joëlle; De Cuypere, Eveline; Jerzak, Katarzyna; Chia, Stephen; Maraldo, Maja; Rønlev, Jeanette; Brix, Eva; Tanner, Minna; Mattson, Johanna; Huovinen, Riikka; Wimberger, Pauline; Reinisch, Mattea; Tesch, Hans; Untch, Michael; Fasching, Peter; Park-Simon, Tjoung-Won; Tio, Joke; Braun, Michael; Maria Grischke, Eva; Marmé, Frederik; van Mackelenbergh, Marion; McCaffrey, John; De Laurentiis, Michelino; Caruso, Michele; Berardi, Rossana; Biganzoli, Laura; Fotia, Vittoria; Yamashita, Toshinari; Tsurutani, Junji; Tsugawa, Koichiro; Tomioka, Nobumoto; de Boer, Maaike; Houtsma, Daniel; Pilskog, Martin; Engebråten, Olav; Sætersdal, Anna; Wysocki, Piotr; Nowecki, Zbigniew; Radecka, Barbara; Jassem, Jacek; Duchnowska, Renata; Simões, Joana; Cardoso, Fatima; Rita Sousa, Ana; Jesús Vidal Losada, María; Saura Manich, Cristina; Gavilá Gregori, Joaquin; Pilar Lopez Marti, Maria; Ruiz Borrego, Manuel; Cortés Castán, Javier; López López, Rafael; Rodríguez Sanchez, César; González Flores, Encarnación; Hinojo González, Carmen; Martínez del Prado, Purificación; Schiza, Aglaia; Killander, Fredrika; Klint, Leif; Rossi, Lorenzo; Aebi, Stefan; Zaman, Khalil; Hall, Peter; Anders, Carey

doi:10.1038/s41591-024-03261-7

Public

Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: a phase 3b/4 trial

Published in Nature Medicine • Sep 13, 2024

Authors:

Nadia Harbeck

Eva Ciruelos

Guy Jérusalem

Abstract

Abstract Trastuzumab deruxtecan (T-DXd) intracranial activity has been observed in small or retrospective patient cohorts with human epidermal growth factor receptor 2–positive (HER2 + ) advanced/metastatic breast cancer (mBC) and stable or active (untreated/previously treated and progressing) brain...

Subject

Trastuzumab

Medicine

Breast cancer

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