Darolutamide in Combination With Androgen-Deprivation Therapy in Patients With Metastatic Hormone-Sensitive Prostate Cancer From the Phase III ARANOTE Trial

Saad, Fred; Vjaters, Egils; D. Shore, Neal; Olmos, David; Xing, Nianzeng; Juliana Gomes, Andrea; César de Andrade Mota, Augusto; Salman, Pamela; Jievaltas, Mindaugas; Ulys, Albertas; Jakubovskis, M.; Kopyltsov, Evgeny; Han, Weiqing; Nevalaita, Liina; Testa, Isabella; Le Berre, Marie‐Aude; Kuss, Iris; Parambath Haresh, Kunhi; Ganju, Vinod; Gurney, Howard; E. Krieger, Laurence; Kwatra, Vineet; Sewak, Sanjeev; Gwendolyn Stevanovic, Amanda; Weickhardt, Andrew; A. Azambuja, Alan; Mavignier Cárcano, Flavio; Gonçalves Costa, Mateus; José Silva Melo Cruz, Felipe; de Menezes, Juliana; Andreé Joseph de Pádua, Charles; Augusto Peclat de Paula, Adriano; Eugênio Escovar, Carlos; Leite Couto Fernandez, Fabio; Gampel, O.; Juliana Gomes, Andrea; Luz, Murilo; Marinho dos Santos, Gisele; César de Andrade Mota, Augusto; Nogueira, Lucas; D’Almeida Preto, Daniel; C. Sant'Anna, Alexandre; Arima Tiscoski, Katsuki; Giddens, Jonathan; Kenneth Jansz, G.; Kim, Julian; Quellette, Paul; Saad, Fred; Vrabec, George; Acevedo Gaete, Alejandro; Caglevic Medina, Christian; Domínguez Cruzat, Javier; Garrido Salvo, Marcelo; Arroyo, Pedro; Salazar Huerta, Anibal; Salman Boghikian, Pamela; Daniela Valenzuela Velasquez, Yasna; Osvaldo Zwenger, Ariel; Fu, Cheng; Guo, Hongqian; Han, Weiqing; Jiang, Haowen; Jiang, Junhui; Jiang, Shusuan; Li, Lie; Liu, Tongzu; Liu, Zhenhua; Ma, Lulin; Qi, Jun; Qiu, Mingxing; Shi, Guowei; Tian, Ye; Wan, Ben; Wang, Chun-xi; Wang, Dongwen; Wang, Shaogang; Wang, Xiaolin; Wei, Shaozhong; Wu, Jitao; Xiao, Jun; Xie, Keji; Xie, Liping; Xing, Nianzeng; Xue, Boxin; Yan, Zejun; Yang, Yongsheng; Yu, Zhixian; Zhang, Dahong; Zheng, Song; Zhou, Fangjian; G. Advani, Suresh; Agarwal, Pawan; Bhatt, Niraj; Biswajit, Dubashi; Biswas, Ghanashyam; Bondarde, Shailesh; J. Das, Chandan; Das Majumdar, SarojKumar; Gupta, Sujoy; Parambath Haresh, Kunhi; V. James, Francis; Jeyaraj, Pamela; Joshi, Amit; Kalyan, Suman; Kashyapi, Bhalchandra; Kaushal, Ashish; Krishnappa, Raghunath; S. Mavuduru, Ravimohan; Nagarkar, Rajanish; Panchal, Harsha; Parkash, Gourav; Philips, Ashwin; Kumar Pooleri, Ginil; Prabha, Vikram; Kumar Rathnam, Krishna; Ravel, Naveen; Rawal, Sudhir; Rakesh Reddy, Boya; Shah, Manasi; Voonna, Praveena; Aleksandrovs, Andrejs; Jakubovskis, M.; Laukmanis, Alvis; Lietuvietis, V.; Vejins, Mareks; Vjaters, Egils; Jievaltas, Mindaugas; Ulys, Albertas; Venckus, Raimundas; Želvys, A.; Bax, Kevin; Gilling, Peter; Holmes, Michael; Tan, Alvin; Manuel Morante Deza, Carlos; Juan Pazos Franco, Alberto; Fernando Salas Sanchez, Jorge; Figueroa Torrejon, Alejandro; Andabekov, Timur; Atduev, Vagif; Chapko, Yana; Fadeeva, Natalya; Filippov, Alexander; Gafanov, Rustem; Gladkov, Oleg; Каспаров, Борис; Kholtobin, Denis; Kopyltsov, Evgeny; П. Лыков, А.; Nechaeva, Marina; Plekhanov, Alexey; Safina, Sufia; Semenov, Andrey; Shkolnik, Mikhail; Skopin, Pavel; V. Smirnov, R.; Solovyeva, Ekaterina; В. Султанбаев, А.; O. Zavyalov, M.; V. Zyryanov, Alexandr; Chabane, Khabane; Coetzee, Corlia; Jacobs, Conrad; Madlala, Thamsanqa; Malan, Jorn; Mathijs, Sophie; Llorente Abarca, Carlos; Castellano Gauna, D.E.; Álvarez-Ossorio Fernández, J.L.; Gallardo Díaz, Enrique; Borrega García, Pablo; Herrera‐Imbroda, Bernardo; Medina López, R.A.; María Gaya Sopena, Josep; Chung, Hsiao‐Jen; Huang, Shu‐Pin; Tsai, Yuh-Shya; Wang, Pai-Fu; Wang, Shian‐Shiang; Bondarenko, Igor; Golovko, Yurii; Ivashchenko, Petro; M. Paramonov, V.

doi:10.1200/jco-24-01798

Public

Darolutamide in Combination With Androgen-Deprivation Therapy in Patients With Metastatic Hormone-Sensitive Prostate Cancer From the Phase III ARANOTE Trial

Published in Journal of Clinical Oncology • Sep 16, 2024

Authors:

Fred Saad

Egils Vjaters

Neal D. Shore

Abstract

PURPOSE For patients with metastatic hormone-sensitive prostate cancer (mHSPC), delaying progression to castration-resistant disease is important not only for overall survival (OS) but also for patients' quality of life. Darolutamide plus androgen-deprivation therapy (ADT) with docetaxel improved OS...

Subject

Docetaxel

Medicine

Androgen deprivation therapy

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