PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators

Wang, Yuexi; V. Chembazhi, Ullas; Yee, Danielle; Chen, Sijie; Ji, Jie; Wang, Yujie; Lam Nguyen, Ka; Lin, PoChing; Ratti, Antonia; A. Hess, Rex; Qiao, Huanyu; Ko, CheMyong; Yang, Jing; Kalsotra, Auinash; Mei, Wenyan

doi:10.1093/nar/gkae862

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PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators

Published in Nucleic Acids Research • Oct 7, 2024

Authors:

Yuexi Wang

Ullas V. Chembazhi

Danielle Yee

Abstract

Spermatogenesis is a biological process within the testis that produces haploid spermatozoa for the continuity of species. Sertoli cells are somatic cells in the seminiferous epithelium that orchestrate spermatogenesis. Cyclic reorganization of the Sertoli cell actin cytoskeleton is vital for sperma...

Subject

Biology

Cell biology

Sertoli cell

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