Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma

Gallitto, Matthew; Zhang, Xu; De Los Santos, Genesis; Wei, Hong-Jian; Calvo Fernández, Ester; Duan, Shoufu; Sedor, Geoffrey; Yoh, Nina; Kokossis, Danae; Carlos Angel, J; Wang, Yifang; J. White, Erin; J. Kinslow, Connor; Berg, Xander; Tomassoni, Lorenzo; Zandkarimi, Fereshteh; In Christine Chio, Iok; Canoll, Peter; N. Bruce, Jeffrey; A. Feldstein, Neil; D. Gartrell, Robyn; K. Cheng, Simon; H. Garvin, James; Zacharoulis, Stergios; J. Wechsler‐Reya, Robert; Pavisic, Jovana; Califano, Andrea; Zhang, Zhiguo; Wu, Cheng–Chia

doi:10.1093/neuonc/noae215

Public

Targeted delivery of napabucasin with radiotherapy improves outcomes in diffuse midline glioma

Published in Neuro-Oncology • Oct 12, 2024

Authors:

Matthew Gallitto

Xu Zhang

Genesis De Los Santos

Abstract

BACKGROUND: Diffuse midline glioma (DMG) is the most aggressive primary brain tumor in children. All previous studies examining the role of systemic agents have failed to demonstrate a survival benefit; the only standard of care is radiation therapy (RT). Successful implementation of radiosensitizat...

Subject

Radiosensitizer

Medicine

In vivo

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