Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirzepatide

J. Jalleh, Ryan; P. Plummer, Mark; S. Marathe, Chinmay; M. Umapathysivam, Mahesh; R. Quast, Daniel; K Rayner, Christopher; L Jones, Karen; Wu, Tongzhi; Horowitz, Michael; A. Nauck, Michael

doi:10.1210/clinem/dgae719

Public

Clinical Consequences of Delayed Gastric Emptying With GLP-1 Receptor Agonists and Tirzepatide

Published in The Journal of Clinical Endocrinology & Metabolism • Oct 10, 2024

Authors:

Ryan J. Jalleh

Mark P. Plummer

Chinmay S. Marathe

Abstract

CONTEXT: Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are established therapeutics for type 2 diabetes and obesity. Among other mechanisms, they slow gastric emptying and motility of the small intestine. This helps to limit postprandial glycemic excursions and reduce chylomicron formation...

Subject

Gastric emptying

Medicine

Gastroparesis

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