FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver

Wang, Haizhen; Nikain, Cyrus; Fortounas, Konstantinos; Amengual, Jaume; Tufanlı, Özlem; La Forest, Maxwell; Yu, Yong; C. Wang, Meng; Watts, Russell; Lehner, Richard; Qiu, Yunping; Cai, Min; J. Kurland, Irwin; J. Goldberg, Ira; Rajan, Sujith; Mahmood Hussain, M.; L. Brodsky, Jeffrey; A. Fisher, Edward

doi:10.1016/j.molmet.2024.102048

Public

FITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver

Published in Molecular Metabolism • Oct 18, 2024

Authors:

Haizhen Wang

Cyrus Nikain

Konstantinos Fortounas

Abstract

Triglycerides (TGs) associate with apolipoprotein B100 (apoB100) to form very low density lipoproteins (VLDLs) in the liver. The repertoire of factors that facilitate this association is incompletely understood. FITM2, an integral endoplasmic reticulum (ER) protein, was originally discovered as a fa...

Subject

Lipid-anchored protein

Apolipoprotein B

Very low-density lipoprotein

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