Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma

Fandrei, David; Seiffert, Sabine; Rade, Michael; Rieprecht, Susanne; Gagelmann, Nico; Born, Patrick; Wiemers, Thomas; Weidner, Heike; Kreuz, Markus; Schassberger, Tamara; Koßmann, Jannik; Mangold, Marlene; Fürst, Daniel; Fischer, Luise; Baber, Ronny; Heyn, Simone; Yau Wang, Song; Bach, Enrica; Hoffmann, Sandra; H. Metzeler, Klaus; Herling, Marco; Jentzsch, Madlen; Franke, Georg-Nikolaus; Köhl, Ulrike; Friedrich, Maik; Boldt, Andreas; Reiche, Kristin; Platzbecker, Uwe; Vucinic, Vladan; Merz, Maximilian

doi:10.1158/2643-3230.bcd-24-0118

Public

Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma

Shared by NobleBlocks on Oct 23, 2024 • 12:00 AM UTC

Authors:

David Fandrei

Sabine Seiffert

Michael Rade

Abstract

Abstract Establishing a strategy for sequencing of T cell–redirecting therapies for relapsed/refractory multiple myeloma (RRMM) is a pressing clinical need. We longitudinally tracked the clinical and immunologic impact of bispecific T cell–engaging antibodies (BsAb) as bridging therapy (BT) to subse...

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