Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation

Dubois, Bruno; Villain, Nicolas; S. Schneider, Lon; C. Fox, Nick; L. Campbell, Noll; Galasko, Douglas; Kivipelto, Miia; Jessen, Frank; Hanseeuw, Bernard; Boada, Merçé; Barkhof, Frederik; Nordberg, Agneta; Froelich, Lutz; Waldemar, Gunhild; Steen Frederiksen, Kristian; Padovani, Alessandro; Planche, Vincent; C. Rowe, Christopher; Bejanin, Alexandre; Ibáñez, Agustín; F. Cappa, Stefano; Caramelli, Paulo; Nitríni, Ricardo; Allegri, Ricardo; Slachevsky, Andrea; Cruz de Souza, Leonardo; Bozoki, Andrea; Widera, Eric; Blennow, Kaj; Ritchie, Craig; Agronin, Marc; Lopera, Francisco; Delano‐Wood, Lisa; Bombois, Stéphanie; Lévy, Richard; Thambisetty, Madhav; Georges, Jean; T. Jones, David; Lavretsky, Helen; M. Schott, Jonathan; R. Gatchel, Jennifer; Swantek, Sandra; Newhouse, Paul; Feldman, Howard; B. Frisoni, Giovanni

doi:10.1001/jamaneurol.2024.3770

Public

Alzheimer Disease as a Clinical-Biological Construct—An International Working Group Recommendation

Published in JAMA Neurology • Nov 1, 2024

Authors:

Bruno Dubois

Nicolas Villain

Lon S. Schneider

Abstract

Importance: Since 2018, a movement has emerged to define Alzheimer disease (AD) as a purely biological entity based on biomarker findings. The recent revision of the Alzheimer's Association (AA) criteria for AD furthers this direction. However, concerns about a purely biological definition of AD bei...

Subject

Construct (python library)

Disease

Alzheimer's disease

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