From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression

E. Graham, Sarah; Dmitrieva, Mariia; B. Vendramini‐Costa, Débora; Francescone, Ralph; A. Trujillo, María; Cukierman, Edna; D. Wood, Laura

doi:10.1093/carcin/bgae064

Public

From precursor to cancer: decoding the intrinsic and extrinsic pathways of pancreatic intraepithelial neoplasia progression

Published in Carcinogenesis • Oct 2, 2024

Authors:

Sarah E. Graham

Mariia Dmitrieva

Débora B. Vendramini‐Costa

Abstract

This review explores the progression of pancreatic intraepithelial neoplasia (PanIN) to pancreatic ductal adenocarcinoma through a dual lens of intrinsic molecular alterations and extrinsic microenvironmental influences. PanIN development begins with Kirsten rat sarcoma viral oncogene (KRAS) mutatio...

Subject

Pancreatic cancer

Pancreatic Intraepithelial Neoplasia

Cancer research

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!