Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting.

VR, Minciacchi; J, Bravo; C, Karantanou; RS, Pereira; C, Zanetti; R, Kumar; N, Thomasberger; P, Llavona; T, Krack; K, Bankov; M, Meister; S, Hartmann; V, Maguer-Satta; S, Lefort; M, Putyrski; A, Ernst; BJP, Huntly; E, Meduri; W, Ruf; DS, Krause

doi:10.1038/s41467-024-54361-4

Public

Exploitation of the fibrinolytic system by B-cell acute lymphoblastic leukemia and its therapeutic targeting.

Shared by NobleBlocks on Nov 20, 2024 • 12:00 AM UTC

Authors:

Minciacchi VR

Bravo J

Karantanou C

Abstract

Fibrinolysis influences the mobilization of hematopoietic stem cells from their bone marrow microenvironment (BMM). Here we show that activation of plasmin, a key fibrinolytic agent, by annexin A2 (ANXA2) distinctly impacts progression of BCR-ABL1+ B-cell acute lymphoblastic leukemia (B-ALL) via mod...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!