Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation

Tong, Huan; X. Jiang, Z.; Song, Linlin; Tan, Keqin; Yin, Xiaomeng; He, Changtong; Huang, Juan; Li, Xiaoyue; Jing, Xiaofan; Hong, Yun; Li, Guangqi; Zhao, Yunuo; Kang, Qianlong; Wei, Yuhao; Li, Renwei; Long, Zhiwen; Yin, Jun; Luo, Qiang; Liang, Xiao; Wan, Yi; Zheng, Aiping; Lin, Nan; Zhang, Tao; Xu, Jiayi; Yang, Xinggang; Jiang, Yuting; Li, Yueyi; Yu, Xiang; Zhang, Yu; Feng, Lusi; Lei, Zhen; Shi, Hubing; Ma, Xuelei

doi:10.1016/j.cmet.2024.10.019

Public

Dual impacts of serine/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation

Published in Cell Metabolism • Nov 21, 2024

Authors:

Huan Tong

Z. X. Jiang

Linlin Song

Abstract

The effect of the serine/glycine-free diet (-SG diet) on colorectal cancer (CRC) remains unclear; meanwhile, programmed death-1 (PD-1) inhibitors are less effective for most CRC patients. Here, we demonstrate that the -SG diet inhibits CRC growth and promotes the accumulation of cytotoxic T cells to...

Subject

Evasion (ethics)

Glycine

Serine

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!