Metabolic modelling links Warburg effect to collagen formation, angiogenesis and inflammation in the tumoral stroma

Cancer cells are known to express the Warburg effect—increased glycolysis and formation of lactic acid even in the presence of oxygen—as well as high glutamine uptake. In tumors, cancer cells are surrounded by collagen, immune cells, and neoangiogenesis. Whether collagen formation, neoangiogenesis, ... View More