Cardiovascular events observed among patients in the etrasimod clinical programme: an integrated safety analysis of patients with moderately to severely active ulcerative colitis

Vermeire, Séverine; T. Rubin, David; Peyrin-Biroulet, Laurent; C. Dubinsky, Marla; Regueiro, Miguel; M. Irving, Peter; Goetsch, Martina; Lazin, Krisztina; Gu, Guibao; Wu, Joseph; Modesto, Irene; McDonnell, Aoibhinn; Guo, Xiang; Green, Jesse; B Dalam, Alexis; Yarur, Andrés

doi:10.1136/bmjgast-2024-001516

Public

Cardiovascular events observed among patients in the etrasimod clinical programme: an integrated safety analysis of patients with moderately to severely active ulcerative colitis

Published in BMJ Open Gastroenterology • Jan 1, 2025

Authors:

Séverine Vermeire

David T. Rubin

Laurent Peyrin-Biroulet

Abstract

OBJECTIVE: receptor expression on cardiac cells is involved in cardiac conduction. We report cardiovascular treatment-emergent adverse events (TEAEs) associated with S1P receptor modulators and other cardiovascular events in the etrasimod UC clinical programme. METHODS: Patients were analysed in the...

Subject

Medicine

Bradycardia

Internal medicine

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