Human Serum Albumin Loaded with Fatty Acids Reveals Complex Protein-Ligand Thermodynamics and Boleadora-Type Solution Dynamics Leading to Gelation

Hinderberger, Dariush; Reichenwallner, Jörg; Michler, Sebastian; Schwieger, Christian

doi:10.26434/chemrxiv-2025-7fhz2

Public

Human Serum Albumin Loaded with Fatty Acids Reveals Complex Protein-Ligand Thermodynamics and Boleadora-Type Solution Dynamics Leading to Gelation

Published in ChemRxiv • Feb 6, 2025

Authors:

Dariush Hinderberger

Jörg Reichenwallner

Sebastian Michler

Abstract

Using an electron paramagnetic resonance (EPR) spectroscopic strategy that has been developed for core-shell polymers, the complexity of the binding of fatty acids to human serum albumin (HSA) is characterized in detail. We unravel the internal dynamics of HSA solutions with fatty acids by applying ...

Subject

Electron paramagnetic resonance

Human serum albumin

Dynamic light scattering

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