Characterization of Plasma Cell-Free DNA Variants as of Tumor or Clonal Hematopoiesis Origin in 16,812 Advanced Cancer Patients

Magee, Daniel; Domenyuk, Valeriy; Abraham, Jim; Perdigones Borderias, Nieves; Swensen, Jeffrey; Solipuram, Praveena; Ayanambakkam, Adanma; Mehdi, Raja; Challagalla, Jagathi; I. Heath, Elisabeth; Landsverk, Megan; Jurkiewicz, Magdalena; Shimkus, Brian; Pinto, Ian; Patterson, Daniel; Hsiehchen, David; Koya, Supriya; G. Somer, Bradley; Velez, Michel; F. Shields, Anthony; L. Cultrera, Jennifer; R. Ribeiro, Jennifer; Hahn-Lowry, Robert; W. Sledge, George; J. Oberley, Matthew; Radovich, Milan; Spetzler, David

doi:10.1158/1078-0432.ccr-24-3335

Public

Characterization of Plasma Cell-Free DNA Variants as of Tumor or Clonal Hematopoiesis Origin in 16,812 Advanced Cancer Patients

Published in Clinical Cancer Research • Feb 11, 2025

Authors:

Daniel Magee

Valeriy Domenyuk

Jim Abraham

Abstract

PURPOSE: Plasma-based liquid biopsy tests can detect tumor-specific genetic alterations and offer many advantages that complement tissue-based comprehensive genomic profiling. However, age-related clonal hematopoiesis (CH) mutations can confound liquid biopsy results and potentially lead to incorrec...

Subject

Liquid biopsy

Buffy coat

Biology

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