Estrogen synthesized in the central nervous system enhances <scp>MC</scp> 4 <scp>R</scp> expression and reduces food intake

Hayashi, Takanori; Kumamoto, Kanako; Kobayashi, Tatsuya; Hou, Xinfeng; Nagao, Shizuko; Harada, Nobuhiro; Honda, Shin‐ichiro; Shimono, Yohei; Nishio, Eiji

doi:10.1111/febs.17426

Public

Estrogen synthesized in the central nervous system enhances MC 4 R expression and reduces food intake

Published in FEBS Journal • Feb 18, 2025

Authors:

Takanori Hayashi

Kanako Kumamoto

Tatsuya Kobayashi

Abstract

Estrogen is synthesized throughout various tissues in the body, and its production is regulated by the rate-limiting enzyme aromatase (encoded by the Cyp19a1 gene). Notably, aromatase is also expressed in central nervous system cells, allowing for localized estrogen synthesis in regions such as the ...

Subject

Estrogen

Food science

Biology

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