Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial

Couturaud, Françis; Schmidt, Jeannot; Sanchez, Olivier; Ballerie, Alice; Sevestre, Marie‐Antoinette; Méneveau, Nicolas; Bertoletti, Laurent; Connault, J.; Benhamou, Y.; Constans, J.; Quéméneur, T.; Lapébie, François-Xavier; Pernod, Gilles; Picart, Gaël; Élias, Antoine; Doutrelon, C.; Neveux, Claire; Khider, Lina; Roy, P.M.; Zuily, Stéphane; Falvo, Nicolas; Lacroix, Philippe; Emmerich, Joseph; Mahé, Isabelle; Boileau, J.; Yaïci, Azzedine; Le Jeune, Sylvain; Stéphan, Dominique; Plissonneau-Duquene, Pierre; Ray, Valérie; Danguy des Déserts, Marc; Belhadj-Chaidi, R.; Lamia, Bouchra; Gruel, Yves; Presles, Émilie; Girard, Philippe; Tromeur, Cécile; Moustafa, Farès; Rothstein, Vincent; Lacut, Karine; Mélac, Solen; Barillot, Sophie; Mismetti, Patrick; Laporte, Silvy; Mottier, Dominique; Meyer, Guy; Leroyer, Christophe; Barnier, Aude; Bazire, Amélie; ANDRE, Norbert; Gut-Gobert, Christophe; Lemoigne, Emmanuelle; Le Mao, Raphaël; de Saint Martin, Luc; Astruc, Nolwenn; de Moreuil, Claire; Bressollette, Luc; Frachon, I.; Pasquier, Élisabeth; Savary, Xavier; Guellec, Dewi; Pan‐Petesch, Brigitte; Baudino, Laurent; Gestin, Simon; Hoffmann, Clément; PRONOST, Pauline; Fauché, Alexandre; Orione, Charles; Nepveu, Olivier; Hourmant, Baptiste; Accassat, Sandrine; De Magalhaes, Élodie; Buchmuller, Andréa; Le Hello, C; POENOU, Géraldine; Pastré, Jean; Briend, G.; Roche, Anne; Gazeau, Benoit; Planquette, Benjamin; Goudot, Guillaume; Seinturier, C.; Zenati, N.; BLAISE, Sophie; Menez, C.; Imbert, B.; Yver, J; Jégo, P.; ALLAIN, Jean-Sébastien; Henriot, Basile; Bura-Rivière, A.; Delaunay, J.; Mokaddem, Wassim; ROQUES, Morgane; DUNOYER, Géraud; Moine, Thomas; KNAFO, Gabriel; Thery, Arthur; VANNIER, Maxime; BRUNI, Sarah; JAMMES, Thomas; COSTANZO, Christophe; Thévenot, F.; BILLARD, R.; Verset, Lucas; GILLETTE, Charles; AIZEL, Ghali; CORVAISIER, Florent; BRUCHES, Lucie; NZITA, Coralia; Guillon, Benoît; Chopard, Romain; Serzian, Guillaume; Besutti, Matthieu; MORIS, Marlène; Yahia, M; STEIN, Gauthier; Monnin, Charles; Lacroix, Philippe; Désormais, Ileana; Le Jeunne, Claire; Szwebel, Tali‐Anne; Marey, Jonathan; Lorut, Christine; Parent, Florence; Jovan, Roland; Montani, David; Jaïs, Xavier; Jevnikar, Mitja; Jutant, Etienne‐Marie; Moumneh, Thomas; Douillet, Delphine; Journeau, L.; GUINEMER, Sylvie; Plaisance, L.; POENOU, Géraldine; Toledano, Emmanuel; Jandot, Maud; LEDAN, Frédérik; Fréchier, Léo; Duhamel, E; Cârlan, Maria; Ducornet, A.; Breuil, N.; Heuser, S.; Giroud, G; Billault, C.; Dublanchet, N.; SORTAIS, Elise; VALENTIN, Jean-baptistre; Ardillon, Laurent; Bouteau, Jérémie; Soudet, Simon; Le Roy, Gaëlle; Dupas, S.; Samy Modeliar, S.; Dhamy, A.; JOANNIDES, Marion; Armengol, G.; Damian, Louise; KERVARREC, Chloé; Membrey, B.; Le Besnerais, M.; Marie, Isabelle; Miranda, S.; FARES, Yara; Simon, Delphine; SINZOGAN-EYOUM, Calliste; MASMOUDI-BELAALA, Sounda; Van Den Bogaert, Ann; J. Wu, Abraham; LAMMENS, Justine; Ferrari, Émile; Cornand, Dimitri; CORNE, Anais; BENTIBA, Ghezlan; Daoud-Elias, Marie; POGGI, Jean-noël; MARTINEZ, Pauline; REZKALLAH, Sarah; Pangnarind, V.; Aquilanti, Sandro; Pan‐Petesch, Brigitte; Castella, N; El Kouri, D.; Blanc, F.–X.; Pottier, P.; Morin, Jean; Gueffet, I.; Pavageau, Laure; BLAISE, Pauline; GUIMARD, Camillle; Guyot, Sarah-Lou; Kenzi, A; Latour, Chloé; LE MOULLEC, Julien; LAURENT, Steven; Artifoni, Mathieu; Gautier, Giovanni; Raimbeau, Alizée; Goffinet, Nicolas; DURAND, Cécile; Ploton, Gaëtan; Bry, C.; De Carvalho, Hugo; JOUBERT, Oihan; Hervé, C; Ribes, Simon; G Du Chene, A; CHEVALIER, Chloé; Espitia, Olivier; BAZILE, Marion; TOSTAIN-HENOC, Nadege; GUITTET, Marie; Rob J Gallas, P; PATRON, Anthony; Crestani, Bruno; Skopinski, S.; Le Moal, Charlène; Coudene, Alice; MANDON, Claire; Carcaud, Claire; Boulon, Carine; BENZEKRI, Sofian; Dari, Loubna; MEHLAL-SEGHAR, Fatiha; Russier, M.; CAMPANA, Marion; GORALSKI, Marc; Rohel, G.; RIVIERE, Emilie; Niakara, A; Vergne, F.; Danguy des Déserts, Marc; Bisseriex, H.; SIMSON, Jean-Pierre; Ferrière, Nicolas; ERTZSCHEID, Clémence; Rousseau Legrand, Claire; GUELLEC, Dewi; Roseau, J.-B.; Dufrost, Virginie; Zieminski, Piotr; ESCOLANO, Marine; GARNICHE, Vincent; Sauvage, Alexis; Rigaux, Camille; KRAFFT, Alix; Larue, Alexandrine; CAMPI, Alexis; Noyé, Mickaël; Brisot, D.; Wautot, A; de la Fuente, P.; BROUSSE, Christophe; Messas, Emmanuel; Mirault, Tristan; Galloula, A.; Zarka, Samuel; Guillet, Matthieu; Khider, Lina; Darnige, Luc; MACE DE GASTINES, Alban; Goudot, Guillaume; Sitruk, Jonas; Gourdier, Anne-Sophie; Montaclair, Karine; VAUGOUX, Elodie; TIGAS-MOLINIER, Daniela; Kern, Léa; Ray, Valérie; Proust, Alain; MNIF, Dorra; ROUGIER, Marion; PALEIRON, Nicolas; Barazzutti, H.; Bérard, H.; Rohel, G.; Rogé, C.; Lambert, Yannick; Gadby, Florence; ANDRO, Cécile; Renault, David; Abbes, Sarah; Kittirath, Christine; FAYARD, Samuel; Le Gouellec, N.; HAOUIOUI, Camy; Rousselin, Clémentine; Hidden, V.; DESRUMAUX, Sophie; LEONE, Nathalie; DOUTRELON, Caroline; Martin, Anne-Céline; Alcaix, D.; Zarnitsky, Charles; Langlois, Vincent; A. Moukarzel, A.; Huchot, Eric; Benaïnous, Ruben; Lopez‐Sublet, Marilucy; Bloch‐Queyrat, Coralie; Al‐Nawakil, Chadi; Lévy, Vincent; Angoulvant, Denis; Ivanes, Fabrice; Darwiche, Walid; Genet, T; Stéphan, Dominique; Cordeanu, Elena‐Mihaela; Heitz, Marie; Lambach, H.; Pianezze, M.; Tousch, Jonathan; Bayle, Sandrine; Gorka, Hervé; Socié, Pierre; Dutoiu, Téodora; Rangé, Grégoire; Albert, Franck; Thuaire, Christophe; Demichéli, T; Roussel, Laurent; Khalil, Cliff; Dasoveanu, Madalina; Loghin, Caterina; Attal, Raphaël; Michon-Pasturel, U.; Delrue, Maxime; Bonhomme, S.; MILONGO, Vanessa; Jaillette, Clément; Yannoutsos, Alexandra; Mauger, Chadi; Le Brun, Charles; GUILLEMOT, Sandra; PETITPAS, Marie-Laure; Bazin, Yann; ALLAIN, Jean-Sébastien; Thépault, Fanny; Roux, Damien; Lanéelle, Damien; Guillaumat, Jérôme; Radureau, Chloé; Pottier, Camille; Di Candia, Angela; BALHADJ, Rafik; Macchi, Laurent; Trihan, Jean-Eudes; Croquette, Magali; Brebion, Nicolas; Kubina, Jean-Manuel; LEBLANC, Chloé; HERVE, Henri

doi:10.1016/s0140-6736(24)02842-3

Public

Extended treatment of venous thromboembolism with reduced-dose versus full-dose direct oral anticoagulants in patients at high risk of recurrence: a non-inferiority, multicentre, randomised, open-label, blinded endpoint trial

Published in The Lancet • Feb 27, 2025

Authors:

Françis Couturaud

Jeannot Schmidt

Olivier Sanchez

Abstract

BACKGROUND: In patients with venous thromboembolism at high risk of recurrence for whom extended treatment with direct oral anticoagulants has been indicated, the optimal dose is unknown. We aimed to assess efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants in patients i...

Subject

Medicine

Venous thromboembolism

Clinical endpoint

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