Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases

Sanchez, Erlan; Coughlan, Gillian; Wilkinson, Tim; Ramirez, Joel; Saeed Mirza, Saira; Baril, Andrée‐Ann; A. Dilliott, Allison; Frank, Andrew; E. Lang, Anthony; Hassan, Ayman; G. Pollock, Bruce; J.M. Scott, Christopher; Marras, Connie; E. Fischer, Corinne; Seitz, Dallas; Andriuta, Daniela; Dowlatshahi, Dar; A. Grimes, David; F. Tang‐Wai, David; J. Sahlas, Demetrios; Rogaeva, Ekaterina; Finger, Elizabeth; F. Robinson, John; Tan, Kübra; A. Binns, Malcolm; Carmela Tartaglia, Maria; Borrie, Michael; J. Strong, Michael; Ozzoude, Miracle; D. Nanayakkara, Nuwan; A. Gonçalves, Rafaella; Bartha, Robert; A. Hegele, Robert; M.K. Farhan, Sali; E. Black, Sandra; Kumar, Sanjeev; Symons, Sean; Mohammad Hassan Haddad, Seyyed; Pasternak, Stephen; R. Arnott, Stephen; K. Rajji, Tarek; Steeves, Thomas; Swardfager, Walter; J. Ashton, Nicholas; Kvartsberg, Hlin; Zetterberg, Henrik; P. Munoz, Douglas; Masellis, Mario; the ONDRI Investigators, for

doi:10.1212/wnl.0000000000213438

Public

Association of Plasma Biomarkers With Longitudinal Atrophy and Microvascular Burden on MRI Across Neurodegenerative and Cerebrovascular Diseases

Published in Neurology • Mar 10, 2025

Authors:

Erlan Sanchez

Gillian Coughlan

Tim Wilkinson

Abstract

BACKGROUND AND OBJECTIVES: Plasma biomarkers of Alzheimer disease (AD), neuroinflammation, and neurodegeneration are increasingly being used in clinical trials for diagnosis and monitoring of dementia. However, their association with longitudinal structural brain MRI changes, an important outcome me...

Subject

Atrophy

Medicine

Association (psychology)

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