TriNetX and Real-World Evidence: A Critical Review of Its Strengths, Limitations, and Bias Considerations in Clinical Research

Nassar, Mahmoud; Abosheaishaa, Hazem; Elfert, Khaled; Beran, Azizullah; Ismail, Abdellatif; Mohamed, Mouhand; Misra, Anoop; Amir Essibayi, Muhammed; Altschul, David; Y. Azzam, Ahmed

doi:10.71079/aside.im.03222516

Public

TriNetX and Real-World Evidence: A Critical Review of Its Strengths, Limitations, and Bias Considerations in Clinical Research

Published in ASIDE Internal Medicine • Mar 21, 2025

Authors:

Mahmoud Nassar

Hazem Abosheaishaa

Khaled Elfert

Abstract

Introduction: The increasing utilization of real-world data platforms in medical research necessitates a comprehensive understanding of their methodological strengths and limitations. TriNetX has emerged as a significant platform for exploring large healthcare datasets. This review aims to criticall...

Subject

Generalizability theory

Data science

Reliability (semiconductor)

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