A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils.

G, Martinez-Rivas; MV, Ayala; S, Bender; GR, Codo; WK, Swiderska; A, Lampis; L, Pedroza; M, Merdanovic; P, Sicard; E, Pinault; L, Richard; F, Lavatelli; S, Giorgetti; D, Canetti; A, Rinsant; S, Kaaki; C, Ory; C, Oblet; J, Pollet; E, Naser; A, Carpinteiro; M, Roussel; V, Javaugue; A, Jaccard; A, Bonaud; L, Delpy; M, Ehrmann; F, Bridoux; C, Sirac

doi:10.1038/s41467-025-58307-2

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A mouse model of cardiac immunoglobulin light chain amyloidosis reveals insights into tissue accumulation and toxicity of amyloid fibrils.

Shared by NobleBlocks on Mar 27, 2025 • 12:00 AM UTC

Authors:

Martinez-Rivas G

Ayala MV

Bender S

Abstract

Immunoglobulin light chain (LC) amyloidosis (AL) is one of the most common types of systemic amyloidosis but there is no reliable in vivo model for better understanding this disease. Here, we develop a transgenic mouse model producing a human AL LC. We show that the soluble full length LC is not tox...

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