Artemether-Lumefantrine Treatment Selects <i>Plasmodium falciparum</i> Multidrug Resistance 1 (<i>pfmdr1</i>) Increased Copy Number Among African Malaria Infections

Fançony, Cláudia; Fortes-Gabriel, Elsa; Zage, Félix; Alexiou, Evangelia; Broumou, Ioanna; Pernaute-Lau, Leyre; Panzo, Jorge; J António, Esperança; S Cristovão, Mario; M Domingos, José; Sassoma, Estevão; Kuatoko, Fernando; Rosário, Edite; Martins, A.; Färnert, Anna; Bernardino, Luís; Nóbrega de Sousa, Taís; Pedro Gil, José

doi:10.1093/infdis/jiaf155

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Artemether-Lumefantrine Treatment Selects Plasmodium falciparum Multidrug Resistance 1 (pfmdr1) Increased Copy Number Among African Malaria Infections

Published in The Journal of Infectious Diseases • Mar 26, 2025

Authors:

Cláudia Fançony

Elsa Fortes-Gabriel

Félix Zage

Abstract

BACKGROUND: Decreased efficacy of artemether-lumefantrine, the globally most used antimalarial, has recently emerged in Africa. METHODS: An efficacy trial was carried out based on directly observed artemether-lumefantrine therapy at Bengo, Northern Angola. One-hundred Plasmodium falciparum uncomplic...

Subject

Plasmodium falciparum

Malaria

Artemether/lumefantrine

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