Spatially resolved atlas of breast cancer uncovers intercellular machinery of venular niche governing lymphocyte extravasation

Wang, Xin; Wang, Zhanyu; Liao, Qijun; Yuan, Pei; Mei, Junpu; Zhang, Yin; Wu, Chao; Kang, Xiyu; Zheng, Sufei; Yang, Chenxuan; Liu, Jiaxiang; Shang, Qingyao; Li, Jiangtao; Wang, Bingning; Li, Liangyu; Liu, Hui; Hu, Weining; Dong, Zhensheng; Zhao, Jie; Wang, Linying; Liu, Tao; Den, Yusheng; Wang, Chengrui; Han, Lijuan; Chen, Qianjun; Yang, Huanming; Xu, Xun; He, Jie; Yue, Zhen; Sun, Nan; Fang, Xiaodong; Ying, Jianming

doi:10.1038/s41467-025-58511-0

Public

Spatially resolved atlas of breast cancer uncovers intercellular machinery of venular niche governing lymphocyte extravasation

Published in Nature Communications • Apr 9, 2025

Authors:

Xin Wang

Zhanyu Wang

Qijun Liao

Abstract

Breast cancers present intricate microenvironments comprising heterotypic cellular interactions, yet a comprehensive spatial map remained to be established. Here, we employed the DNA nanoball-based genome-wide in situ sequencing (Stereo-seq) to visualize the geospatial architecture of 30 primary bre...

Subject

Extravasation

Niche

Breast cancer

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