Activation of lysosomal iron triggers ferroptosis in cancer

Cañeque, Tatiana; Baron, Leeroy; Müller, Sebastian; Carmona, Alanis; Colombeau, Ludovic; Versini, Antoine; Solier, Stéphanie; Gaillet, Christine; Sindikubwabo, Fabien; L. Sampaio, Júlio; Sabatier, Marie; Mishima, Eikan; Picard–Bernes, Armel; Syx, Laurène; Servant, Nicolas; Lombard, Bérangère; Loew, Damarys; Zheng, Jiashuo; Proneth, Bettina; K. Thoidingjam, Leishemba; Grimaud, Laurence; Fraser, Cameron; J. Szylo, Krystina; Der Kazarian, Emma; Bonnet, Caroline; Charafe‐Jauffret, Emmanuelle; Ginestier, Christophe; Santofimia‐Castaño, Patricia; Estarás, Matías; Dusetti, Nelson; Iovanna, Juan; Sá Cunha, António; Pittau, Gabriella; Hammel, Pascal; Tzanis, Dimitri; Bonvalot, Sylvie; Watson, Sarah; Gandon, Vincent; Upadhyay, Aditya; A. Pratt, Derek; Porto Freitas, Florêncio; Pedro Friedmann Angeli, José; R. Stockwell, Brent; Conrad, Marcus; M. Ubellacker, Jessalyn; Rodriguez, Raphaël

doi:10.1038/s41586-025-08974-4

Public

Activation of lysosomal iron triggers ferroptosis in cancer

Published in Nature • May 7, 2025

Authors:

Tatiana Cañeque

Leeroy Baron

Sebastian Müller

Abstract

Iron catalyses the oxidation of lipids in biological membranes and promotes a form of cell death called ferroptosis1. Defining where this chemistry occurs in the cell can inform the design of drugs capable of inducing or inhibiting ferroptosis in various disease-relevant settings. Genetic approaches...

Subject

Cancer cell

Cell biology

Programmed cell death

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