In silico screening of a designed targeted chemical space identifies novel alkyl hydrazides as potent HDAC11 inhibitors

The therapeutic potential of HDAC inhibitors containing a hydroxamic acid moiety as a zinc-binding group (ZBG) is limited in clinical use due to their potential mutagenicity. In addition, hydroxamic acids often exhibit off-target effects that can lead to undesirable toxicity. Therefore, the developm... View More