Identification and targeting of regulators of SARS-CoV-2–host interactions in the airway epithelium

Dirvin, Brooke; Noh, Heeju; Tomassoni, Lorenzo; Cao, Dianbo; Zhou, Yizhuo; Ke, Xiangyi; Qian, Jun; Jangra, Sonia; Schotsaert, Michael; García‐Sastre, Adolfo; Karan, Charles; Califano, Andrea; V. Cardoso, Wellington

doi:10.1126/sciadv.adu2079

Public

Identification and targeting of regulators of SARS-CoV-2–host interactions in the airway epithelium

Published in Science Advances • May 16, 2025

Authors:

Brooke Dirvin

Heeju Noh

Lorenzo Tomassoni

Abstract

The impact of SARS-CoV-2 in the lung has been extensively studied, yet the molecular regulators of host-cell programs hijacked by the virus in distinct human airway epithelial cell populations remain poorly understood. Some of the reasons include overreliance on transcriptomic profiling and use of n...

Subject

Biology

Transcriptome

Cell biology

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