Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients

Walsh, Timothy; S. Walsh, Timothy; Parker, Richard; M. Aitken, Leanne; McKenzie, Cathrine; M. Emerson, Lydia; Boyd, Julia; Macdonald, Alix; Beveridge, Gayle; E B Giddings, A; Hope, David; Rodman Irvine, S.; Tuck, Sharon; I. Lone, Nazir; Kydonaki, Kalliopi; Norrie, John; Brealey, David; Antcliffe, David; Reay, Michael; Williams, Alan; Bewley, Jeremy; Creagh-Brown, Benedict; F. McAuley, Daniel; Dark, Paul; P. Wise, Matt; C. Gordon, Anthony; D. Perkins, Gavin; C. Reade, Michael; Blackwood, Bronagh; M. J. MacLullich, Alasdair; Glen, Robert; J. Page, Valerie; J. Weir, Christopher; Trial Investigators, A2B; Pattison, Natalie; Williams, Barry; Rose, Louise; Mouncey, Paul; Prowle, John; Wellsted, David; Walsh, Tim; Walsh, Tim; J. 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doi:10.1001/jama.2025.7200

Public

Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients

Published in JAMA • May 19, 2025

Authors:

Timothy Walsh

Timothy S. Walsh

Richard Parker

Abstract

Importance: Whether α2-adrenergic receptor agonist-based sedation, compared with propofol-based sedation, reduces time to extubation in patients receiving mechanical ventilation in the intensive care unit (ICU) is uncertain. Objective: To evaluate whether dexmedetomidine- or clonidine-based sedation...

Subject

Dexmedetomidine

Sedation

Medicine

Research Assistant

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