Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients

S. Walsh, Timothy; A. Parker, Richard; M. Aitken, Leanne; A. McKenzie, Cathrine; Emerson, Lydia; Boyd, Julia; Macdonald, Alix; Beveridge, Gayle; Giddings, Annabel; Hope, David; Irvine, Sîan; Tuck, Sharon; I. Lone, Nazir; Kydonaki, Kalliopi; Norrie, John; Brealey, David; Antcliffe, David; Reay, Michael; Williams, Alan; Bewley, Jeremy; Creagh-Brown, Benedict; F. McAuley, Daniel; Dark, Paul; P. Wise, Matt; C. Gordon, Anthony; D. Perkins, Gavin; C. Reade, Michael; Blackwood, Bronagh; MacLullich, Alasdair; Glen, Robert; J. Page, Valerie; J. Weir, Christopher; Trial Investigators, A2B; Pattison, Natalie; Williams, Barry; Rose, Louise; Mouncey, Paul; Prowle, John; Wellsted, David; Walsh, Tim; Brett, Stephen; Charles, Heather; Weir, Christoper; Norrie, John; Bion, Julian; McLennan, Graeme; Stevenson, Matt; Nichol, Alistair; Walsh, Timothy; Amamio, Maria; Barclay, Lucy; Birch, Sophie; Briton, Kate; Clark, Sarah; Crossan, Jessica; Doverman, Katherine; Hope, David; Macdonald, Lucy; McCulloch, Corrienne; Rae, Nicola; Simpson, Scott; Singleton, Jo; Wishart, Maggie; Thompson, Ruth; Aitken, Neill; Fairlie, Rachel; Salim, Nabeel; Talbot, Sam; Ackroyd, Sarah; Alicino, Valeria; Allan, Euan; Anderson, Thomas; Andrew, Rosemary; Baigey, Andrew; Baillie, Kenneth; Barnetson, Calum; Begbie, Ruth; Biggers, Richie; Blaney, Michael; Broom, Richard; Birrell, David; Calkin, Will; Chuavilong, Keegan; Cowden, Rebecca; Cox, Thomas; Darjee, Coral; Davies, Simon; Docherty, Annemarie; Dornan, Luke; Dunn, Mark; Edwardson, Stuart; Gillespie, Ross; Greenwood, Jane; Griffith, David; Hay, Alasdair; Hu, Amy; Hunter, Ali; Jones, Karen; Jordan, Helen; Joseph, Ancy; Kefala, Kallirroi; Kelly, Stephanie; Kemp, Laura; Kubanova, Bara; Leng, Victoria; Livesey, John; Lone, Nazir; Lyon, James; Mansfield, Olivia; McAvoy, Dean; McClatchey, Aaron; Miller, Jonathan; Mirchandani, Ananda; Moffitt, Peter; Morrison, Steven; Muir, Alexandra; Nunn, Kieran; Ochiltree, John; Ogden, Emily; Parks, Matthew; Pass, Marc; Penrose, Rachael; Putnam, Harry; Quinn, Thomas; Rhodes, Jonathan; Rollings, Alexander; Ross, Stephen; Shackleton, Ralph; Shankar, Manu; Sharma, Sunil; Slessor, Iain; Slevin, Zack; Stickle, Duncan; Symons, Louise; Walker, Fiona; Walls, Luke; Whiteford, Ian; Yin Yong, Sue; Young, Neil; Rooney, Kevin; Kinsella, Michael; Digby, Brian; Brett, Michael; McConnell, Paul; Henderson, Mark; Sundaram, Radha; Gemmell, Lisa; Christie, Fiona; Henderson, Philip; MacGregor, Fiona; Henderson, Steven; Rodden, Natalie; Fallon, Kirsty; Abel, Lynn; McLaren, Barbara; Hughes, Emma; McGlynn, Deborah; Thomson, Nicola; Walker, Lauren; Currie, Susan; Parker, Natasha; Gillan, Donna; Brohi, Farooq; Purvis, Sarah; Clark, Michele; Race, Pam; Williams, Lynne; Shahin, Ahmed; Nworah, Eusebius; Gui, Jonathan; Cheng, Li-Chin; Stewart, Katelyn; Cusack, Rebecca; Tomlin, Mark; Bolger, Clare; Burnish, Rachel; Jackson, Sue; Baker, Alice; Biss, Jonathan; Salmon, Karen; Carter, Michael; McKenzie, Catherine; Elsheikh, Razaz; (Anne) Harrison, Missy; Thomas, Charlotte; Ward, James; Cumpstey, Andrew; Dushianthan, Ahilanandan; Kemp, Ivan; Page, Valerie; Zhao, Xiaobei; Nordin, Nazril; Hegazy, Ahmed; Hoxha, Elvira; Hardaker, Owen; Ede, Chimenime; Kotrikova, Nailia; Devaraja, Acharya; Stambach, Thomas; Mukherjee, Prasun

doi:10.1001/jama.2025.7200

Public

Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients

Published in JAMA • Jul 1, 2025

NobleIDark:/48914/w1/20260526/F7FD66E5Record on NobleID

Authors:

Timothy S. Walsh

,

Richard A. Parker

,

Leanne M. Aitken

Abstract

Importance Whether α 2 -adrenergic receptor agonist–based sedation, compared with propofol-based sedation, reduces time to extubation in patients receiving mechanical ventilation in the intensive care unit (ICU) is uncertain. Objective To evaluate whether dexmedetomidine- or clonidine-based sedation...

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