Intravenous Tenecteplase before Thrombectomy in Stroke

Qiu, Zhongming; Li, Fengli; Sang, Hongfei; Yuan, Guangxiong; Xie, Dongjing; Zhou, Kai; Li, Maohua; Meng, Zhaoyou; Kong, Zhenyu; Ruan, Zhongfan; Li, Chaoqun; Yang, Guangui; Wu, Junxiong; Chen, Long; Yang, Bo; Hu, Hai; Li, Yanling; Luo, Jun; Shi, Zhonghua; Huang, Xianjun; Jiang, Shunfu; Yi, Tingyu; Zeng, Guoyong; Liu, Jincheng; Luo, Xiao‐Jun; Liu, Shudong; Chang, Mingze; Wu, Youlin; Tang, Yufeng; Tian, Zhenxuan; Yan, Zhizhong; Zhao, Haojin; Peng, Yuqi; Dai, Hongguo; Zhou, Peiyang; Li, Huagang; Liu, Wenhua; Song, Dengwen; Lei, Bo; Xia, Zhongbin; Tan, Xiaolin; Zhao, Maojun; Feng, Xinggang; Cai, Lingyu; Li, Qi; Wu, Yuelu; Jiang, Bingwu; Tian, Yan; Li, Linyu; Jiang, Ling; Long, Xing; You, Feng; Tao, Jian; Zhou, Jin; Wu, Derong; Zheng, Chong; Yin, Congguo; Wang, Duolao; Lu, Mengjie; W. Albers, Gregory; G. Nogueira, Raul; Campbell, Bruce; N. Nguyen, Thanh; L. Saver, Jeffrey; Zi, Wenjie; Yang, Qingwu

doi:10.1056/nejmoa2503867

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Intravenous Tenecteplase before Thrombectomy in Stroke

Published in New England Journal of Medicine • May 21, 2025

Authors:

Zhongming Qiu

Fengli Li

Hongfei Sang

Abstract

BACKGROUND: The safety and efficacy of treatment with intravenous tenecteplase before endovascular thrombectomy in patients with acute ischemic stroke due to large-vessel occlusion remain uncertain. METHODS: In this open-label trial conducted in China, we randomly assigned patients with acute ischem...

Subject

Tenecteplase

Medicine

Stroke (engine)

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