Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain development

Panasenkava, Veranika; Garreau, Jules; Guyodo, Hélène; Diab, Farah; Mahieux, Ariane; Carré, Wilfrid; Verrès, Yann; Jullion, Emmanuelle; Odent, Sylvie; Dubourg, Christèle; Rollier, Paul; Dubos, Lauryane; Ribes, Vanessa; Camus, Anne; de Tayrac, Marie; Dupé, Valérie

doi:10.1101/2025.05.20.654466

Public

Mapping the temporal and functional landscape of Sonic Hedgehog signaling reveals new insights into early human forebrain development

Published in bioRxiv (Cold Spring Harbor Laboratory) • May 21, 2025

Authors:

Veranika Panasenkava

Jules Garreau

Hélène Guyodo

Abstract

SUMMARY The early patterning of the anterior neuroectoderm constitutes a fundamental blueprint for human brain development, orchestrated by multiple signaling pathways. Among them, Sonic Hedgehog (SHH) plays a key influence. However, the transcriptional programs it engages remain poorly defined due ...

Subject

Forebrain

Sonic hedgehog

Hedgehog

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