Conformational Change in a Four‐Tetrad DNA G‐Quadruplex upon Intercalation of a Small‐Molecule Ligand PyDH2

N. Martin, Kailey; Lam, Gwendolyn; Reznichenko, Oksana; E. Brunner, Kyle; J. Zdilla, Michael; McCarthy, Sawyer; Granzhan, Anton; A. Yatsunyk, Liliya

doi:10.1002/anie.202501443

Public

Conformational Change in a Four‐Tetrad DNA G‐Quadruplex upon Intercalation of a Small‐Molecule Ligand PyDH2

Published in Angewandte Chemie International Edition • May 22, 2025

Authors:

Kailey N. Martin

Gwendolyn Lam

Oksana Reznichenko

Abstract

Abstract G‐quadruplexes (G4s) are non‐canonical DNA structures implicated in a number of biological processes. Small‐molecule ligands can alter stability and folding of G4s, which can potentially be exploited for therapeutic purposes. In this work, we investigate the interaction of telomeric DNA fra...

Subject

Antiparallel (mathematics)

Tetrad

Chemistry

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