Pharmacokinetic/Pharmacodynamic Modelling and Monte Carlo Simulations to Predict Cytomegalovirus Viral Load in Pediatric Transplant Recipients Treated with (val)Ganciclovir

Koloskoff, Kévin; Franck, Bénédicte; Bénito, Sylvain; Welzel, Julien; Autmizguine, Julie; Théorêt, Yves; Briand, Annabelle; Ovetchkine, Philippe; Woillard, Jean‐Baptiste

doi:10.1007/s40262-025-01526-z

Public

Pharmacokinetic/Pharmacodynamic Modelling and Monte Carlo Simulations to Predict Cytomegalovirus Viral Load in Pediatric Transplant Recipients Treated with (val)Ganciclovir

Published in Clinical Pharmacokinetics • May 24, 2025

Authors:

Kévin Koloskoff

Bénédicte Franck

Sylvain Bénito

Abstract

Cytomegalovirus (CMV) infection poses significant challenges in pediatric transplant recipients. Ganciclovir and its prodrug valganciclovir are primary treatments because of their potent antiviral effects. Balancing efficacy and toxicity is particularly critical in children. This study aimed to deve...

Subject

Ganciclovir

Pharmacokinetics

Pharmacodynamics

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