Tumor Treating Fields With Gemcitabine and Nab-Paclitaxel for Locally Advanced Pancreatic Adenocarcinoma: Randomized, Open-Label, Pivotal Phase III PANOVA-3 Study

M. Babiker, Hani; J. Picozzi, Vincent; R Chandana, Sreenivasa; Melichar, Bohuslav; Kasi, Anup; Gang, Jin; Gallego, Javier; Bullock, Andrea; Chunyi, Hao; Wyrwicz, Lucjan; Hitre, Erika; Osipov, Arsen; de la Fouchardière, Christelle; Alés, Inmaculada; Dragovich, Tomislav; Jin Lee, Woo; Feeney, Kynan; A. Philip, Philip; Ueno, Makoto; Van Cutsem, Eric; Seufferlein, Thomas; Macarulla, Teresa; behalf of the PANOVA-3 Study Investigators, on; R. Spigel, David; Osipov, Arsen; Matrana, Marc; Blondin, Nicholas; Lou, Emil; T. Shroff, Rachna; Orr, Douglas; J. Anderson, Michael; F. Shields, Anthony; Hamm, John; Bullock, Andrea; Nagireddy, Sumana; Kolodney, Joanna; Dragovich, Tomislav; L. Coveler, Andrew; Maniam, Ajit; J. Picozzi, Vincent; D. Sears, Judith; Stilwill, Joseph; P. Arena, Francis; Cusnir, Mike; Niewiaroska, Anna; Small, William; Kasi, Anup; Tache, Jason; Ross, Sharona; Shihabi, Samer; Gandhi, Sunil; N. Reeves, J.; Green, Garrett; Feinstein, Trevor; K. Huyck, Timothy; Ramdin, Nadia; Marsh, Robert; Jiang, Yixing; Hatoum, Hassan; Manda, Sudhir; D. Kochenderfer, Mark; Illum, Henrik; Richards, Donald; Valilis, P.; Wong, Lucas; R Chandana, Sreenivasa; B. Newton, Herbert; Abdelrahim, Maen; Einspahr, David; Siegel, Richard; McKenney, Scott; Narang, Mohit; Uemura, Marc; R. Cárdenes, Higinia; Thanikachalam, Kannan; P. Raff, Joshua; Ye, Joseph; Behl, Deepti; E. Kam, Audrey; DeRose, Paul; Tasneem, A.; Brenner, Warren; De Los Santos, Jennifer; Z. Wang, James; C Rausch, D; Trikha, Gaurav; Park, Jae‐Hyun; Gabrail, Nashat; B. Mowat, Rex; Jahangir, Khawaja; P. Schumaker, Robert; Soffen, Edward; Bravin, Eric; Kumar Gupta, Mukul; M. Babiker, Hani; Dario Bedoya-Apraez, Ivan; Y. Kang, Tyler; Lemay, Frédéric; Vincent, Mark; Létourneau, Richard; Fuchs, Martin; Seufferlein, Thomas; Doehring, Christine; Haberkorn, Mike; Vogel, Arndt; Rußwurm, Karen; Chater, Jack; Küng, Marc; Schacher, Sabine; Passhak, Maria; Geva, Ravit; Hubert, Ayala; M. Stemmer, Salomon; Golan, Talia; Senellart, Hélène; Trouilloud, Isabelle; de la Fouchardière, Christelle; Blan, Jean-Frederic; Dourthe, Luis-Marie; Le Roy, Florence; Martin-Babau, J.; Ben Abdelghani, Méher; Greil, Richard; Schreil, Georg; Gerger, Armin; Eisterer, Wolfgang; Macarulla Mercadé, T.; Cubillo, Antonio; Valladares Pons, Francesc; Guillén‐Ponce, Carmen; Alés Díaz, Inmaculada; Rivera, Fernando; Gállego, Javier; Yayá, Ricardo; Ponz Sarvise, Mariano; Vincenzi, Bruno; Airoldi, Mario; Bellotti, Giovanna; Corsi, Domenico; Antonuzzo, Lorenzo; Melichar, Bohuslav; Holečková, Petra; Petruželka, Luboš; Kotasek, Rostislav; Němeček, Radim; van Cutsem, Eric; Van Laethem, Jean‐Luc; Borbath, Ivan; Hwang, Jun‐Eul; Yong Oh, Sung; Jin Sym, Sun; Hee Lee, Moon; Young Kim, Jin; Cheul Oh, Sang; Jin Lee, Woo; Oh Park, Joon; Won Kim, Jin; Ah Lee, Myung; Jin Choi, Hye; Yun Kang, Seok; Jae Chon, Hong; Wyrwicz, Lucjan; Ramlau, Rodryg; Mruk, Andrzej; Freier, Beata; Anna Kosakowska, Ewa; Kocsis, Judit; Csőszi, Tibor; Hitre, Erika; Al-Farhat, Yousuf; Bassam, A.; Hao, Chunyi; Liang, Bo; Cang, Shundong; Jin, Gang; Zuo, Changzeng; Song, Lijie; Wu, Zheng; Gao, Jie; Zhang, Tao�; Wang, Yusheng; Yuan, Xin; Li, Zhi-Hua; Chen, Rufu; Li, Wei; Cai, Xiujun; Zhu, Zhizhen; Bai, Yuxian; Bai, Chunmei; Yau, Thomas; Joubert, Warren; Yeung Mark Wong, Ka; Marx, Gavin; Feeney, Kynan; Harris, Marion; Mišir, Ana; Faccio, Adilson; Melo Cruz, Felipe; De Azevedo, Srergio; Paula Victorino, Ana; Ferreira Paiva, Tadeu; Franke, Fábio; Arima Tiscoski, Katsuki; Parolla, Gabriel; Lilno, Flora; Bruno Siqueira, Mariana; Lyra, Marcos; M. Hoff, Paulo; Luis Martinez Lira, Jose; Mendoza Oliva, Dolores; Vazquez, Arturo; Elvis Cabrera Luviano, Jesus; Castillo Gutiérrez, Erika; Rosas Camargo, Vanessa; Chavez Guerra, Cristian; Hernandez Flores, Osvaldo; Cortez, David; Campos-Gómez, Saúl; Romarico González Espinoza, Iván; Reyes Contreras, Jessica; Gómez Villanueva, Ángel; Zayas Villanueva, Omar

doi:10.1200/jco-25-00746

Public

Tumor Treating Fields With Gemcitabine and Nab-Paclitaxel for Locally Advanced Pancreatic Adenocarcinoma: Randomized, Open-Label, Pivotal Phase III PANOVA-3 Study

Published in Journal of Clinical Oncology • May 31, 2025

Authors:

Hani M. Babiker

Vincent J. Picozzi

Sreenivasa R Chandana

Abstract

PURPOSE Tumor treating fields (TTFields) use alternating electric fields to disrupt cancer cell proliferation. Feasibility of TTFields therapy with gemcitabine/nab-paclitaxel was previously demonstrated in patients with advanced pancreatic adenocarcinoma. PANOVA-3 was designed to confirm safety and ...

Subject

Gemcitabine

Medicine

Internal medicine

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